AI Article Synopsis
- Orthotopic liver transplantation (OLT) is the preferred treatment for severe liver diseases, but neurological complications can lead to significant morbidity and mortality in post-operative patients.
- A study examined 76 adult OLT patients between 1994 and 2007, finding that 30.3% experienced central nervous system (CNS) complications, with the majority occurring within the first two weeks.
- The most common issues included neurological impairment due to immunosuppressive drugs and peripheral nerve damage, highlighting the serious risks associated with OLT and the concerning outcomes for affected patients.
Article Abstract
Background: Orthotopic liver transplantation (OLT) is the treatment of choice for multiple acute and chronic end-stage liver diseases as well as for selected cases of liver malignancy and liver-site metabolic disorders. Neurological impairment is a major source of morbidity and mortality following OLT.
Aim: To describe the incidence and the type of neurological complications occurring in the post-operative period of OLT in patients transplanted in our hospital.
Material And Methods: Between March 1994 and August 2007, 76 adult patients underwent OLT. Data on incidence, time of onset, and outcome of central nervous system (CNS) complications have been obtained from our program data base and patient charts.
Results: Twenty three patients (30.3%) had CNS complications following OLT. The leading complications were immunosuppressive drug-related neurological impairment in nine patients (39.1%), peripheral nerve damage in five patients (21.7%), central pontine myelinolysis in four patients (17.4%), cerebrovascular disease in three (13%) and CNS infection in three (13%). Most CNS events (90%) occurred in the first 2 weeks after OLT. Five patients with neurological complications died (22%).
Conclusions: CNS complications occurred in almost one fifth of the population studied, and they had a poor outcome, as previously reported).
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