Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor. The sternum is a rare location. To date, only four cases have been reported with detailed information. Here, we present a case with sternal GCT and discuss the clinical manifestation and treatment, in addition to reviewing the literature. A 53-year-old female noted pain in the sternum after a trauma. Radiographic findings revealed an expanding osteolytic lesion in the body of the sternum. Extended curettage of the tumor was performed followed by polymethylmethacrylate (PMMA) filing. No recurrence was found over a 7-year follow-up period. In conclusion, even though sternal benign tumors are rare, GCT should be considered as one of the differential diagnoses in a patient presenting with a sternal lesion in the 5th or 6th decade of life. The initial treatment should be extended curettage followed by filling with PMMA.
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