Background: Periodontal disease is infectious in nature and leads to an inflammatory response. It arises from the accumulation of subgingival bacterial plaque and leads to the loss of attachment, increased probing depth, and bone loss. It is one of the world's most prevalent chronic diseases. In this study we developed and studied metronidazole-loaded 50/50 poly(DL-lactide-co-glycolide) (PDLGA), 75/25 PDLGA, and poly(DL-lactic acid) (PDLLA) films. These films are designed to be inserted into the periodontal pocket and treat infections with controlled-release metronidazole for >or=1 month.
Methods: The structured films were prepared using the solution-casting technique. Concentrated solutions and high solvent-evaporation rates were used to get most of the drug located in the bulk, i.e., in whole film's volume. The effects of copolymer composition and drug content on the release profile, cell growth, and bacterial inhibition were investigated.
Results: The PDLLA and 75/25 PDLGA films generally exhibited a low- or medium-burst release followed by a moderate release at an approximately constant rate, whereas the 50/50 PDLGA films exhibited a biphasic release profile. The drug released from films loaded with 10% weight/weight metronidazole resulted in a significant decrease in bacterial viability within several days. When exposed to human gingival fibroblasts in cell culture conditions, these films maintained their normal fibroblastic features.
Conclusions: This study enabled the understanding of metronidazole-release kinetics from bioabsorbable polymeric films. The developed systems demonstrated good biocompatibility and the ability to inhibit Bacteroides fragilis growth; therefore, they may be useful in the treatment of periodontal diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1902/jop.2009.080216 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pulsed laser deposition assisted epitaxial growth of cesium telluride photocathodes for high brightness electron sources.
Sci Rep
January 2025
IBM T. J. Watson Research Center, Yorktown Heights, NY, 10598, USA.
The development of high-brightness electron sources is critical to state-of-the-art electron accelerator applications like X-ray free electron laser (XFEL) and ultra-fast electron microscopy. Cesium telluride is chosen as the electron source material for multiple cutting-edge XFEL facilities worldwide. This manuscript presents the first demonstration of the growth of highly crystalized and epitaxial cesium telluride thin films on 4H-SiC and graphene/4H-SiC substrates with ultrasmooth film surfaces.
View Article and Find Full Text PDFStructural Basis of Ultralow Capacitances at Metal-Nonaqueous Solution Interfaces.
J Am Chem Soc
January 2025
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211816, China.
Metal-nonaqueous solution interfaces, a key to many electrochemical technologies, including lithium metal batteries, are much less understood than their aqueous counterparts. Herein, on several metal-nonaqueous solution interfaces, we observe capacitances that are 2 orders of magnitude lower than the usual double-layer capacitance. Combining electrochemical impedance spectroscopy, atomic force microscopy, and physical modeling, we ascribe the ultralow capacitance to an interfacial layer of 10-100 nm above the metal surface.
View Article and Find Full Text PDFIn situ synthesis of HKUST-1 on copper-ammonia fiber for preparation of quaternary-ammonium chitosan based active packaging with sustained-release cinnamaldehyde.
Int J Biol Macromol
January 2025
School of Chemistry and Chemical Engineering, Guangxi University, 100 East University Road, Nanning 530004, PR China. Electronic address:
Cinnamaldehyde (CIN) is gaining interest as a highly effective natural antimicrobial agent to extend the shelf life of fruits. However, its inherent instability limits further applications. In this work, a new strategy for the synthesis of HKUST-1 to encapsulate CINs by in situ growth method using copper-ammonia fiber as precursors is proposed.
View Article and Find Full Text PDFSynthesis, characterization and molecular docking of chitin-curcumin based thermoset polyurethane elastomers for angiogenic potential.
Int J Biol Macromol
January 2025
Department of Chemistry, The University of Lahore, Lahore, Pakistan.
This current study has been carried out to investigate the angiogenic potential and in silico studies of designed thermoplastic polyurethanes (PU) for biomedical potential. For this purpose, curcumin based thermoplastic polyurethanes has been synthesized by two step methodology. Different characterization techniques such as FTIR, solid state HNMR, CNMR and XRD were used to confirm the synthesis of designed thermoplastic polyurethanes.
View Article and Find Full Text PDFPreparation and characterization of polyvinyl alcohol and chitosan composite film with cassia oil encapsulated in β-cyclodextrin and its application in fresh banana.
Int J Biol Macromol
January 2025
Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225001, PR China; The Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control (Yangzhou University), Yangzhou 225001, PR China. Electronic address:
In this study, composite films were developed by encapsulating cassia oil (CO) with β-cyclodextrin through a microencapsulation technique and incorporating it into a chitosan (CS), polyvinyl alcohol (PVA) and glycerol matrix. The primary objective of the film was to inhibit bacterial growth on the surface of fresh bananas and extend their shelf life. Characterization methods were employed to evaluate the physical properties and functionality of the composite films.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!