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Emerging Immunotherapies for Disease Modification of Type 1 Diabetes.
Drugs
January 2025
Division of Endocrinology, Department of Pediatrics, College of Medicine, University of Florida, 1699 SW 16th Ave, Building A, Gainesville, FL, 32608, USA.
Type 1 diabetes mellitus (T1DM) is characterized by the progressive, autoimmune-mediated destruction of β cells. As such, restoring immunoregulation early in the disease course is sought to retain endogenous insulin production. Nevertheless, in the more than 100 years since the discovery of insulin, treatment of T1DM has focused primarily on hormone replacement and glucose monitoring.
View Article and Find Full Text PDFIndian Cryogenebank Conserving Diverse Plant Genetic Resources for the Last Three Decades: Achievements and Way Forward.
Cryobiology
January 2025
ICAR-National Bureau of Plant Genetic Resources, New Delhi-110 012 INDIA.
Ex situ conservation of plant genetic resources (PGR) plays a crucial role in sustainable growth and development, as highlighted by the Global Strategy for Plant Conservation (GSPC). Seed genebanks, a key component of ex situ conservation, have been instrumental in preserving plant diversity. However, challenges arise with the conservation of non-orthodox (recalcitrant and intermediate) seeds and vegetative tissues, which are not amenable to storage in traditional genebanks at temperatures of -20°C.
View Article and Find Full Text PDFThe History of the Brazilian Sardine () Between Two Fishery Collapses: An Ecosystem Modeling Approach to Study Its Life Cycle.
Biology (Basel)
December 2024
Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos S/N, 4550-208 Matosinhos, Portugal.
The inter-annual fluctuations of abundance of the Brazilian sardine () during the last decades have deeply modified the purse seine fishery dynamics. This study evaluates the trophic relationships of the main species exploited by this fishery and the importance of its biomass for the southeast-south Brazil marine ecosystem (22° S-34° S). Data were analyzed using a mass balance model (ECOPATH) between the two fishery collapses: 2000 and 2017.
View Article and Find Full Text PDFSafety and Tolerability of Pivmecillinam During More Than Four Decades of Clinical Experience: A Systematic Review.
Clin Infect Dis
January 2025
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
The recent US Food and Drug Administration approval of pivmecillinam-an oral prodrug of the amidinopenicillin antibiotic mecillinam-presents a valuable opportunity to address the need for new treatments for uncomplicated urinary tract infection (uUTI). We report findings of a systematic literature review of the safety profile of pivmecillinam/mecillinam based on more than 40 years' experience, mainly in Europe and Canada, to describe its tolerability profile and identify any important safety signals. In total, 110 eligible publications were identified describing use of pivmecillinam/mecillinam as monotherapy or in combination, for treatment of uUTI or other infectious conditions.
View Article and Find Full Text PDFRetention forestry involves leaving single or groups of unharvested trees within harvest areas. Patch retention, which resembles structures such as unburned patches remaining after wildfire, is one practice implemented within the framework of Ecosystem-based Forest Management (EBM), which seeks to use natural forests as a model and minimize differences in natural and managed forests. Despite the widespread adoption of patch retention practices, few comparisons of the attributes of postfire and postharvest islands, or their drivers, have been made.
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