In this paper are reported the synthesis and antiprotozoal activity in vitro of 24 1-methylbenzimidazole derivatives (13-36) substituted at position 2 with aminocarbonyl, N-methylaminocarbonyl, N,N-dimethylaminocarbonyl, ethoxycarbonyl, 1-hydroxyethyl and acetyl groups, some of them with chlorine atoms at the benzenoid ring. Compounds 13-36 were more active than metronidazole, the choice drug against Giardia intestinalis and most of them against Trichomonas vaginalis. The most active group of compounds for both parasites was that with a 2-ethoxycarbonyl group (16, 22, 28, 34), independently of the substitution pattern at the benzenoid ring.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2008.12.059DOI Listing

Publication Analysis

Top Keywords

synthesis antiprotozoal
8
antiprotozoal activity
8
1-methylbenzimidazole derivatives
8
benzenoid ring
8
activity novel
4
novel 1-methylbenzimidazole
4
derivatives paper
4
paper reported
4
reported synthesis
4
activity vitro
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!