Objective: To assess selection criteria used to determine eligibility for magnetic resonance-guided focused ultrasound surgery (MRgFUS) for the treatment of symptomatic uterine fibroids; to assess the percentage of patients suitable for MRgFUS.
Study Design: A retrospective analysis of 144 patients seeking minimally invasive treatment options for symptomatic uterine fibroids at a single treatment center. Clinical eligibility for MRgFUS was assessed at a gynecology clinic by a Gynecology research fellow trained in the procedure and suitability was assessed by magnetic resonance imaging. Several techniques were used to mitigate against factors that are contra-indications for MRgFUS.
Results: 100% of patients interested in MRgFUS were deemed clinically eligible for the procedure and 74% were deemed technically suitable to proceed with treatment.
Conclusions: Mitigation techniques allow for less restrictive MRgFUS selection criteria for treatment for symptomatic uterine fibroids. These less restrictive criteria are expected to expand the pool of patients for whom MRgFUS is a viable treatment option for uterine fibroid symptoms.
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http://dx.doi.org/10.1016/j.ejogrb.2008.12.011 | DOI Listing |
Uterine fibroids (UFs) are the most common non-cutaneous tumors in women worldwide. UFs arise from genetic alterations in myometrial stem cells (MM SCs) that trigger their transformation into tumor initiating cells (UF SCs). Mutations in the RNA polymerase II Mediator subunit MED12 are dominant drivers of UFs, accounting for 70% of these clinically significant lesions.
View Article and Find Full Text PDFBMC Womens Health
January 2025
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.36 Sanhao Street, Heping District, Shenyang, Liaoning Province, 110004, China.
Background: Uterine cystic adenomyosis is a rare form of focal adenomyosis that is primarily located within the myometrium. In this case report, we present a unique case of adult uterine cystic adenomyosis found outside the uterus following laparoscopic myomectomy.
Case Presentation: The patient was a 36-year-old Chinese woman who had previously undergone laparoscopic surgery at our hospital to remove a 4 cm diameter diameter uterine fibroid six years prior.
Cureus
December 2024
Department of Obstetrics and Gynecology, Kastamonu Training and Research Hospital, Kastamonu, TUR.
Mesothelial cysts in the uterus are exceedingly rare. A 41-year-old patient presented with complaints of abdominal pain, and transvaginal ultrasonography revealed an enlarged uterus with a hypoechoic intramural cystic mass measuring 7.2 × 3.
View Article and Find Full Text PDFCureus
December 2024
Department of Urology, Mamata Academy of Medical Sciences, Hyderabad, IND.
In this case study, we describe a 46-year-old male presenting with a palpable, gradually enlarging scrotal mass persisting over three to four years, ultimately diagnosed as paratesticular leiomyoma, who underwent enucleation of the tumor with no signs of recurrence, two years after surgery. This report underscores the significance of accurate diagnosis to avoid unnecessary treatment. We also emphasize the sequential events and findings, supported by relevant literature review, that contributed to establishing the correct diagnosis and guiding appropriate treatment decisions.
View Article and Find Full Text PDFFront Physiol
December 2024
Department of Radiology, Yiyang Central Hospital, Yiyang, China.
Objectives: To evaluate the effectiveness of an MRI radiomics stacking ensemble learning model, which combines T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (CE-T1WI) with deep learning-based automatic segmentation, for preoperative prediction of the prognosis of high-intensity focused ultrasound (HIFU) ablation of uterine fibroids.
Methods: This retrospective study collected data from 360 patients with uterine fibroids who underwent HIFU treatment. The dataset was sourced from Center A (training set: N = 240; internal test set: N = 60) and Center B (external test set: N = 60).
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