[Vaccination in patients with cirrhosis].

Presse Med

Université Paris Descartes, Faculté de Médecine, INSERM CIC BT 505, AP-HP, Groupe Hospitalier Cochin-Saint Vincent de Paul, CIC de Vaccinologie Cochin Pasteur, Pôle de Médecine, F-75679, Paris Cedex 14, France.

Published: July 2009

Patients with cirrhosis are immunocompromised and have an increased risk of infection, with a worse outcome. Some of those infections may be prevented by vaccination. Immunization can reduce the morbidity and mortality associated with cirrhosis. Immunizations against hepatitis A and B viruses, influenza and pneumococcus are recommended by the French Haute Autorité de Santé since 2007. Vaccination against hepatitis A is recommended in non-immunized cirrhotic patients. Vaccination against hepatitis B is recommended in every cirrhotic patient with no serological markers, and post-vaccinal antibodies titer should be checked. Annual influenza immunization can be done in cirrhotic patients, and pneumococcal polysaccharide vaccination should be repeated after 5 years. Few data regarding vaccination coverage are available, but studies suggest that immunization rates are too low in this population.

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Source
http://dx.doi.org/10.1016/j.lpm.2008.11.015DOI Listing

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