https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=19184989&retmode=xml&tool=Litmetric&email=readroberts32@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09 191849892009052220240511
1439-76331042009Mar02Chembiochem : a European journal of chemical biologyChembiochemA peptide antagonist of the TLR4-MD2 interaction.645649645-910.1002/cbic.200800769Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling.SlivkaPeter FPFDepartment of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA.ShridharMiteshMLeeGui-inGISammondDeanne WDWHutchinsonMark RMRMartinkoAlexander JAJBuchananMadison MMMSholarPage WPWKearneyJeffrey JJJHarrisonJacqueline AJAWatkinsLinda RLRYinHangHengDA 017670DANIDA NIH HHSUnited StatesDE 017782DENIDCR NIH HHSUnited StatesT32 GM065103-07GMNIGMS NIH HHSUnited StatesT32 GM-065103GMNIGMS NIH HHSUnited StatesK05 DA024044DANIDA NIH HHSUnited StatesDA 024044DANIDA NIH HHSUnited StatesR01 DA017670DANIDA NIH HHSUnited StatesR01 DE017782DENIDCR NIH HHSUnited StatesT32 GM065103GMNIGMS NIH HHSUnited StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't
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