Unilateral neglect is usually caused by right hemisphere damage from stroke, leading to difficulties in attending to stimuli in the left perceptual hemifield. As an example, a patient suffering from neglect may read only the right part of a word or the right part of sentences, or eat only from the right side his plate. Neglect is more common, and most often more severe, following infarcts in the right hemisphere than the left. Brain damage leading to neglect usually involves infarcts in the inferior parietal lobe, temporo-parietal junction and/or the superior temporal lobe. Most theories of the nature of neglect assume that neglect involves dysfunctional attentional mechanisms. Increased understanding of neglect has led to the development of several effective therapeutic interventions, where prism adaptation has received the most attention in recent years. This article reviews brain damage in neglect, theories of neglect, therapeutic methods for neglect and their possible future developments.
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Nature
January 2025
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more. Three-finger toxins (3FTx) are highly toxic components of elapid snake venoms that can cause diverse pathologies, including severe tissue damage and inhibition of nicotinic acetylcholine receptors, resulting in life-threatening neurotoxicity. At present, the only available treatments for snakebites consist of polyclonal antibodies derived from the plasma of immunized animals, which have high cost and limited efficacy against 3FTxs.
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January 2025
Department of Mechanical Engineering, Faculty of Engineering, Urmia University, Urmia, Iran.
This study investigates the nonlinear dynamics of a system with frequency-dependent stiffness using a MEMS-based capacitive inertial sensor as a case study. The sensor is positioned directly on a rotating component of a machine and consists of a microbeam clamped at both ends by fixed supports with a fixed central proof mass. The nonlinear behavior is determined by electrostatic forces, axial and bending motion coupling, and frequency-dependent stiffness.
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January 2025
International Livestock Research Institute, P.O. Box 30709, Nairobi, 00100, Kenya.
To address food and nutrition security in the face of burgeoning global populations and erratic climatic conditions there is a need to include nutrient dense, climatic resilient but neglected indigenous fruit trees in agrifood systems. Here we present the draft genome sequence of Kei Apple, Dovyalis afra, a neglected indigenous African fruit tree with untapped potential to contribute to nutrient security and improved livelihoods. Our long-read-based genome assembly comprises 440 Mbp sequence across 1190 contigs with a N50 and L50 of 13.
View Article and Find Full Text PDFSchizophrenia (Heidelb)
January 2025
Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
In West Africa, the long-term consequences of poor early psychosis recovery include poverty, neglect, and community ostracization. To understand the potential for digital health approaches to support early psychosis care in Ghana, we conducted a survey study among early psychosis patients and their caregivers about mental health needs, technology use and access, and interest in digital mental health. Hospital staff at Accra Psychiatric Hospital reviewed hospital medical records from January 2023 - December 2023 identifying young adults (≥18 years old) who had experienced psychosis symptoms for the first time within the prior five years.
View Article and Find Full Text PDFChem Biodivers
January 2025
Universidade Federal de Pernambuco Centro de Biociencias, Centro de Biociências, Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife - PE, 50670-901, 50670-901, Recife, BRAZIL.
Leishmaniasis is a neglected disease caused by parasites of the genus Leishmania sp. that causes approximately 1 million cases and 650,000 deaths annually worldwide. Its treatment has several limitations mainly due to high toxicity and clinical resistance, and the search for alternatives is highly desirable.
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