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Eco-friendly synthesis of silver nanoparticles from peel and juice C. limon and their antiviral efficacy against HSV-1 and SARS-CoV-2.
Virus Res
November 2024
Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy; UOC Patologia e Microbiologia, San Giovanni di Dio e Ruggi D'Aragona University Hospital, 84126 Salerno, Italy. Electronic address:
The growing threat of viral infections requires innovative therapeutic approaches to safeguard human health. Nanomaterials emerge as a promising solution to overcome the limitations associated with conventional therapies. The eco-friendly synthesis of silver nanoparticles (AgNPs) currently represents a method that guarantees antimicrobial efficacy, safety, and cost-effectiveness.
View Article and Find Full Text PDFAssociation between heavy metals exposure and persistent infections: the mediating role of immune function.
Front Public Health
August 2024
School of Public Health, Jilin University, Changchun, China.
Introduction: Persistent infections caused by certain viruses and parasites have been associated with multiple diseases and substantial mortality. Heavy metals are ubiquitous environmental pollutants with immunosuppressive properties. This study aimed to determine whether heavy metals exposure suppress the immune system, thereby increasing the susceptibility to persistent infections.
View Article and Find Full Text PDFModeling antigen-specific T cell dynamics following Hepatitis B Vaccination indicates differences between conventional and regulatory T cell dynamics.
Vaccine
August 2024
Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium; Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium; Antwerp Center for Translational Immunology and Virology (ACTIV), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium; Department of Paediatrics, Antwerp University Hospital, Edegem, Belgium.
Our study aims to investigate the dynamics of conventional memory T cells (Tconv) and regulatory memory T cells (Treg) following activation, and to explore potential differences between these two cell types. To achieve this, we developed advanced statistical mixed models based on mathematical models of ordinary differential equations (ODE), which allowed us to transform post-vaccination immunological processes into mathematical formulas. These models were applied to in-house data from a de novo Hepatitis B vaccination trial.
View Article and Find Full Text PDFEffect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage: protocol for a multicentre, randomised controlled trial (HerpMV).
BMJ Open
April 2024
Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.
Introduction: Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients and is associated with a worse outcome. The aim of this study is to determine whether antiviral therapy in HSV-positive patients improves outcome.
Methods And Analysis: Prospective, multicentre, open-label, randomised, controlled trial in parallel-group design.
Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice.
J Virol
April 2024
Department of Microbiology, New York University School of Medicine, New York, New York, USA.
Article Synopsis
- * A recent study suggested that HSV-1 could also hide in immune cells, but this conclusion was based on flawed single-cell RNA sequencing (scRNA-Seq) data.
- * Our reanalysis revealed issues like neuron destruction and contamination in the data, ultimately concluding that there's little evidence supporting HSV-1 latency in immune cells.
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