A 62 year-old female hemodialysis patient underwent parathyroidectomy to treat secondary hyperparathyroidism. On the preoperative assessment, the plasma levels of parathyroid hormone (PTH) and B-type natriuretic peptide (BNP) were elevated. Echocardiography showed reduced left ventricular (LV) contraction. Myocardial iodine-123-15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid ((123)I-BMIPP) scintigraphy showed moderately reduced tracer uptake in the postero-inferior area on single-photon emission computed tomography and decreased washout on the planar images. After parathyroidectomy, the plasma levels of PTH and BNP decreased, followed by improvement in LV contraction. Myocardial (123)I-BMIPP scintigraphy revealed that the washout on planar images had increased, which suggests that myocardial (123)I-BMIPP scintigraphy is useful for estimating the effect of parathyroidectomy on cardiac function.
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http://dx.doi.org/10.1253/circj.cj-08-0415 | DOI Listing |
Int J Mol Sci
July 2024
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
[I]β-methyl-p-iodophenyl-pentadecanoic acid ([I]BMIPP), which is used for nuclear medicine imaging of myocardial fatty acid metabolism, accumulates in cancer cells. However, the mechanism of accumulation remains unknown. Therefore, this study aimed to elucidate the accumulation and accumulation mechanism of [I]BMIPP in cancer cells.
View Article and Find Full Text PDFJ Imaging
February 2024
Department of Radiology, Kawasaki Municipal Ida Hospital, Kawasaki 211-0035, Japan.
J Imaging
October 2022
Department of Radiology, Kawasaki Municipal Ida Hospital, Kawasaki 211-0035, Japan.
(1) Background: The mortality of breast cancer has decreased due to the advancement of cancer therapies. However, more patients are suffering from cancer-therapeutics-related cardiac dysfunction (CTRCD). Diagnostic and treatment guidelines for CTRCD have not been fully established yet.
View Article and Find Full Text PDFCurr Cardiol Rep
December 2022
Departments of Nuclear Medicine and Cardiovascular Imaging, Diagnóstico Maipú-DASA, Av. Maipú 1668, Vicente López (B1602ABQ), Buenos Aires, Argentina.
Purpose Of Review: Cardiac sarcoidosis (CS) is an inflammatory disease of unknown etiology that can lead to life-threatening arrhythmias, heart failure, and death. Advanced cardiac imaging modalities have improved the clinician's ability to detect this disease. The purpose of this review is to discuss the recent evidence of cardiac metabolic imaging as assessed by [F]FDG PET and [I]BMIPP SPECT in the evaluation of CS patients.
View Article and Find Full Text PDFPurpose: The optimal imaging modality for evaluating Cancer Therapeutics-Related Cardiac Dysfunction (CTRCD) other than echocardiography is currently not known. We conducted a retrospective study utilizing myocardial scintigraphy to detect early-stage CTRCD in asymptomatic breast cancer patients.
Patients And Methods: Fifty-five asymptomatic breast cancer patients who had received chemotherapy within three years were involved in this study.
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