AI Article Synopsis
- Calcium absorption occurs mainly through paracellular flux when intake is sufficient, while transcellular transport is regulated by Vitamin D, which enhances calcium uptake and promotes the protein calbindinD(9k).
- Recent research with knockout mice questions the roles of the calcium channel and calbindin in absorption, suggesting further evaluations are needed.
- Increasing dietary calcium intake is the most effective strategy for ensuring adequate absorption and preventing bone loss, particularly when intake levels are high.
Article Abstract
Calcium absorption proceeds by transcellular and paracellular flux, with the latter accounting for most absorbed calcium when calcium intake is adequate. Vitamin D helps regulate transcellular calcium transport by increasing calcium uptake via a luminal calcium channel and by inducing the cytosolic calcium transporting protein, calbindinD(9k). Recent studies utilizing knockout mice have challenged the functional importance of the channel and calbindin. To integrate the new findings with many previous studies, the function of the two molecules must be evaluated in the calcium transport and economy of mice. When calcium intake is high, transcellular calcium transport contributes little to total calcium absorption. Therefore, increasing calcium intake seems the most effective nutritional approach to ensure adequate absorption and prevent bone loss.
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| http://dx.doi.org/10.1111/j.1753-4887.2008.00147.x | DOI Listing |
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