AI Article Synopsis
- The development of artificial oxygen carriers, like liposome-encapsulated hemoglobin (LEH or TRM-645), aims to address challenges related to blood transfusions and improve oxygen delivery for ischemic diseases.
- The technology involves efficiently encapsulating concentrated hemoglobin and modifying its surface for better stability and shelf life in circulation.
- Initial studies have shown TRM-645's effectiveness and safety as a red blood cell substitute, and further research is underway to prepare for clinical trials and ensure proper manufacturing and quality assurance.
Article Abstract
Clinical application of artificial oxygen carriers as a substitute for blood transfusion has long been expected to solve some of the problems associated with blood transfusion. Use for oxygen delivery treatment for ischemic disease by oxygen delivery has also been examined. These prospective applications of artificial oxygen carriers are, however, still in development. We have developed liposome-encapsulated hemoglobin (LEH), developmental code TRM-645, using technologies for encapsulation of concentrated hemoglobin (Hb) with high encapsulation efficiency as well as surface modification to achieve stability in circulating blood and a long shelf life. We have confirmed the basic efficacy and safety of TRM-645 as a red blood cell substitute in studies on the efficacy of oxygen delivery in vivo, and the safety of TRM-645 has been studied in some animal species. We are now examining various issues related to clinical studies, including further preclinical studies, management of manufacturing and the quality assurance for the Hb solution and liposome preparations manufactured by the GMP facility.
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| http://dx.doi.org/10.1111/j.1525-1594.2008.00699.x | DOI Listing |
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