AI Article Synopsis
- A new compound called brefeldin A formylate (1) was isolated from a Penicillium sp. strain found in a polluted area in Fujian Province, along with two known compounds: brefeldin A (2) and ergosterol (3).
- The structures of these compounds were determined using spectral analysis and X-ray crystallography.
- Brefeldin A formylate (1) showed moderate cytotoxic effects against human lung cancer cells (A549) with an IC(50) value of 18.9 microg/ml in MTT assays.
Article Abstract
A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC(50) value of 18.9 microg/ml by the MTT assay protocol.
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| http://dx.doi.org/10.1080/10286020802513970 | DOI Listing |
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