Mini-open donor nephrectomy (MODN) potentially combines advantages of standard open (SODN) and laparoscopic techniques (LDN). This article is a comparison of these techniques. A literature search was performed for studies comparing MODN with SODN or LDN. Nine studies met our selection criteria. Of the 1038 patients, 433 (42%) underwent MODN, 389 (37%) SODN and 216 (21%) LDN. MODN versus SODN: Operative time (P = 0.17), warm ischemia time (P = 0.20) and blood loss (P = 0.30) were not significantly different. Hospital stay and time to return to work were shorter for MODN by 1.67 days (P < 0.001) and 5 weeks (P = 0.03). Analgesia requirement and overall complications were less in the MODN group (P < 0.001) and (P = 0.03). Ureteric complications (P = 0.21) and 1-year graft survival (P = 0.28) were not significantly different. MODN versus LDN: Operative and warm ischemia times were significantly shorter for the MODN by 55 min (P = 0.005) and 147 s (P < 0.001). Analgesia requirement was greater for the MODN group by 9.62 mEq morphine (P = 0.04). No significant differences were found for blood loss (P = 0.8), hospital stay (P = 0.35), donor complications (P = 0.40) or ureteric complications (P = 0.83). MODN appears to provide advantages for the donor in comparison to SODN and also has a shorter operative time when compared with the LDN.
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http://dx.doi.org/10.1111/j.1432-2277.2008.00828.x | DOI Listing |
PLOS Digit Health
July 2023
Intelligent Global Health Research Group, Machine Learning and Optimization Laboratory, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Clinical Decision Support Systems (CDSS) have the potential to improve and standardise care with probabilistic guidance. However, many CDSS deploy static, generic rule-based logic, resulting in inequitably distributed accuracy and inconsistent performance in evolving clinical environments. Data-driven models could resolve this issue by updating predictions according to the data collected.
View Article and Find Full Text PDFPhys Rev E
March 2022
School of Physics and Optoelectronic Engineering, Anhui University, Hefei, Anhui 230601, China.
We study the percolation of randomly rotating patchy particles on 11 Archimedean lattices in two dimensions. Each vertex of the lattice is occupied by a particle, and in each model the patch size and number are monodisperse. When there are more than one patches on the surface of a particle, they are symmetrically decorated.
View Article and Find Full Text PDFJ Chem Theory Comput
June 2021
Yale Quantum Institute, Yale University, P.O. Box 208334, New Haven, Connecticut 06520-8263, United States.
Optimization algorithms play a central role in chemistry since optimization is the computational keystone of most molecular and electronic structure calculations. Herein, we introduce the iterative power algorithm (IPA) for global optimization and a formal proof of convergence for both discrete and continuous global search problems, which is essential for applications in chemistry such as molecular geometry optimization. IPA implements the power iteration method in quantics tensor train (QTT) representations.
View Article and Find Full Text PDFNano Lett
October 2020
Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Fusion protein tags are widely used to capture and track proteins in research and industrial bioreactor processes. Quantifying fusion-tagged proteins normally requires several purification steps coupled with classical protein assays. Here, we developed a broadly applicable nanosensor platform that quantifies glutathione-S-transferase (GST) fusion proteins in real-time.
View Article and Find Full Text PDFMol Biol Rep
April 2013
Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
It is reported that the autocrine loop of the vascular endothelial growth factor (VEGF) is crucial for the survival and proliferation of non-small cell lung cancer (NSCLC) tumors. In this study we aimed to systematically investigate the role of autocrine vascular VEGF in NSCLC cell line A549 through inhibition of endogenous VEGF. A549 cells were transfected with florescence-labeled VEGF oligodeoxynucleotide with lipofectamine.
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