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Multicenter Hemodynamic Assessment of the LOT-CRT Strategy: When Does Combining Left Bundle Branch Pacing and Coronary Venous Pacing Enhance Resynchronization?: Primary Results of the CSPOT Study.
Circ Arrhythm Electrophysiol
November 2024
Division of Cardiology, University of South Florida Morsani College of Medicine and Tampa General Hospital, Tampa, FL (B.H.).
Article Synopsis
- Left bundle branch area pacing (LBBAP) is being examined as a potential alternative to biventricular pacing (BVP) for patients needing cardiac resynchronization therapy (CRT), with a study comparing the two along with left bundle-optimized therapy CRT (LOT-CRT).
- In the study involving 48 patients, LOT-CRT and BVP showed significantly greater increases in left ventricular pressure and QRS shortening compared to unipolar and bipolar LBBAP, indicating better hemodynamic performance.
- Results also suggested that patients with interventricular conduction delay had less QRS reduction but similar improvements in left ventricular pressure compared to those with left bundle branch block, and the effectiveness of combining LBBAP with coronary vein
Addressing the sources of inter-subject variability in E-field parameters in anodal tDCS stimulation over motor cortical network.
Phys Med Biol
July 2024
Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Although transcranial direct current stimulation constitutes a non-invasive neuromodulation technique with promising results in a great variety of applications, its clinical implementation is compromised by the high inter-subject variability reported. This study aims to analyze the inter-subject variability in electric fields (E-fields) over regions of the cortical motor network under two electrode montages: the classical C3Fp2 and an alternative P3F3, which confines more the E-field over this region.Computational models of the head of 98 healthy subjects were developed to simulate the E-field under both montages.
View Article and Find Full Text PDFAcute anodal transcranial direct current stimulation improves the performance of professional rowers.
Front Sports Act Living
April 2024
Group of Study and Research in Neurorehabilitation and Neuromodulation, Federal University of Espirito Santo, Vitória, Brazil.
Introduction: The aim of the present study was to evaluate the influence of acute transcranial direct current stimulation (tDCS) on physical and subjective responses in professional rowing during the 2,000-m time trial test.
Methods: Seven rowers (age 20.86 ± 4.
Loss of capture of conduction system pacemaker caused by fibrosis surrounding the lead: a case report.
BMC Cardiovasc Disord
December 2023
Department of Cardiology, Amsterdam UMC, Amsterdam, The Netherlands.
Background: Conduction system pacing (CSP) is a novel technique that involves pacing the His-Purkinje system instead of the traditional right ventricular (RV) apex. This technique aims to avoid the adverse effects of RV apical pacing, which can lead to ventricular dyssynchrony and heart failure over time. CSP is gaining popularity but its long-term efficacy and challenges remain uncertain.
View Article and Find Full Text PDFLeft bundle branch pacing with and without anodal capture: impact on ventricular activation pattern and acute haemodynamics.
Europace
October 2023
National Heart and Lung Institute-Cardiovascular Science, The Hammersmith Hospital, Imperial College London, B-Block South, 2nd Floor, Du Cane Road, London W12 0NN, UK.
Aims: Left bundle branch pacing (LBBP) can deliver physiological left ventricular activation, but typically at the cost of delayed right ventricular (RV) activation. Right ventricular activation can be advanced through anodal capture, but there is uncertainty regarding the mechanism by which this is achieved, and it is not known whether this produces haemodynamic benefit.
Methods And Results: We recruited patients with LBBP leads in whom anodal capture eliminated the terminal R-wave in lead V1.
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