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Network pharmacology combines cellular experiments to investigate the anti-inflammatory phytochemicals of vine of Pueraria montana var. lobata and their mechanism.
J Ethnopharmacol
March 2025
Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine - Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, China. Electronic address:
Ethnopharmacological Relevance: Pueraria montana var. lobata (PM) has the effects of relieving muscle stiffness and fever, generating body fluids and quenching thirst, resolving rashes, raising yang and stopping diarrhea, unblocking meridians, and detoxifying alcohol. It is commonly used for the management of conditions including stiff neck and back pain, thirst, diabetes, unresolved measles, external fever with headache, dysentery, diarrhea, dizziness and headache, stroke with hemiplegia, chest and heart pain, and alcohol poisoning.
View Article and Find Full Text PDFInvestigating the measles susceptibility gap in Ontario infants.
Vaccine
March 2025
Public Health Ontario, Toronto, Ontario M5G 1M1, Canada; Centre for Vaccine Preventable Diseases, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada; Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario M5G 1E8, Canada; Department of Paediatrics, University of Toronto, Toronto M5T 3M7, Canada.
Background: Prior to receiving their first dose of measles-containing vaccine, infants may be protected against infection either via antibodies obtained transplacentally from their mothers or by herd immunity. However, there is evidence that transplacental protection may wane well-before the age of first measles vaccination.
Methods: We conducted a cross-sectional study of infants <12 months of age at The Hospital for Sick Children (SickKids) in Toronto, Ontario, and their mothers.
Spatial analysis of measles cases and vaccination coverage in the Somali region, eastern Ethiopia.
Front Epidemiol
February 2025
Public Health Department, Institute of Health Science, Jigjiga University, Jigjiga, Ethiopia.
Background: Measles is a major public health concern that causes morbidity and mortality among children. In 2019, measles incidence reached its highest level in 23 years, with low measles containing vaccine dose one coverage playing a vital role. It can be prevented by two doses of the measles vaccine, either alone or in combination with measles-rubella (MR), which is a low-cost strategy for lowering morbidity and mortality among children.
View Article and Find Full Text PDFEffectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers.
Viruses
February 2025
Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of Korea.
The purpose of this study was to evaluate the effectiveness and immunogenicity of the measles-mumps-rubella (MMR) vaccine against SARS-CoV-2 in healthcare workers at one medical institution. The effectiveness of the MMR vaccine against SARS-CoV-2 was evaluated in overall healthcare workers (HCWs). In addition, neutralizing antibodies to SARS-CoV-2 were measured according to the subjects' measles immunity status with serum samples collected before the coronavirus disease 2019 pandemic period.
View Article and Find Full Text PDFAn outbreak of atypical hand, foot and mouth disease associated Coxsackievirus A6 in children from Cape Verde, 2023.
Virol J
February 2025
Virology Department, Institut Pasteur de Dakar, 36 Avenue Pasteur, 220, Dakar, Senegal.
Background: Rash is a common childhood infection, mainly caused by viruses. Hand, foot, and mouth disease (HFMD), a common viral rash infection, has become one of the most common infectious diseases in Asian countries and caused outbreaks in children and adults worldwide. Following the introduction of enterovirus A71 (EVA71) vaccines, Coxsackievirus A6 (CVA6) has recently emerged.
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