A fluorous-tagged "safety catch" linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only metathesis products. The synthesis of a range of heterocycles is described.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662370 | PMC |
| http://dx.doi.org/10.1021/ol802848j | DOI Listing |
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