The scintillation statistics of broadband acoustic transmissions are determined as a function of signal bandwidth B, center frequency f(c), and range with experimental data in the New Jersey continental shelf. The received signal intensity is shown to follow the Gamma distribution implying that the central limit theorem has led to a fully saturated field from independent multimodal propagation contributions. The Gamma distribution depends on the mean intensity and the number of independent statistical fluctuations or coherent cells micro of the received signal. The latter is calculated for the matched filter, the Parseval sum, and the bandpassed center frequency, all of which are standard ocean acoustic receivers. The number of fluctuations mu of the received signal is found to be an order of magnitude smaller than the time-bandwidth product TB of the transmitted signal, and to increase monotonically with relative bandwidth Bfc. A computationally efficient numerical approach is developed to predict the mean intensity and the corresponding broadband transmission loss of a fluctuating, range-dependent ocean waveguide by range and depth averaging the output of a time-harmonic stochastic propagation model. This model enables efficient and accurate estimation of transmission loss over wide areas, which has become essential in wide-area sonar imaging applications.
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http://dx.doi.org/10.1121/1.3037228 | DOI Listing |
ACS Chem Neurosci
January 2025
School of Medicine, Shanghai University, Shanghai 200444, China.
Noninvasive imaging of β-amyloid is pivotal for the early diagnosis of Alzheimer's disease (AD). While single imaging methods have been extensively studied for detecting Aβ over the past decade, dual-modal probes have received scant attention. In this study, we synthesized and assessed a series of half-curcumin probes, among which demonstrated a high affinity and selectivity for Aβ aggregates.
View Article and Find Full Text PDFAsia Pac J Ophthalmol (Phila)
January 2025
Peking Union Medical College Hospital, Beijing, China. Electronic address:
Purpose: To evaluate the efficacy, durability and safety of intravitreal faricimab versus aflibercept over 48 weeks in patients with neovascular age-related macular degeneration (nAMD) from the LUCERNE China subpopulation.
Design: LUCERNE (NCT03823300) was a phase 3 global, double-masked, active comparator-controlled trial. The China subpopulation comprised patients from mainland China, Taiwan and Hong Kong.
Lancet Rheumatol
January 2025
Department of Rheumatology, Université de Bretagne Occidentale, CHU Brest, INSERM (U1227), LabEx IGO Brest, France.
Background: Moderate doses of glucocorticoids result in improvements in nearly all patients with polymyalgia rheumatica, but related adverse events are common in older individuals. We aimed to evaluate whether treatment with baricitinib (a Janus kinase 1/2 inhibitor) results in disease control without the use of oral glucocorticoids in people with recent-onset polymyalgia rheumatica.
Methods: We conducted a randomised, double-blind, placebo-controlled, parallel-group trial at six expert centres in France.
Background: LIGHT (oLaparib In HRD-Grouped Tumor types; NCT02983799) prospectively evaluated olaparib treatment in patients with platinum-sensitive relapsed ovarian cancer (PSROC) assigned to cohorts by known BRCA mutation (BRCAm) and homologous recombination deficiency (HRD) status: germline BRCAm (gBRCAm), somatic BRCAm (sBRCAm), HRD-positive non-BRCAm, and HRD-negative. At the primary analysis, olaparib treatment demonstrated activity across all cohorts, with greatest efficacy in terms of objective response rate and progression-free survival observed in the g/sBRCAm cohorts. The authors report final overall survival (OS).
View Article and Find Full Text PDFRegulatory T cells (Tregs) are increasingly being recognized for their role in promoting tissue repair. In this issue of the JCI, Chen et al. found that Tregs at the site of bone injury contribute to bone repair.
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