Several secondary metabolites, artemetin (1), casticin (2), 3,3'-dihydroxy-5,6,7,4'-tetramethoxy flavon (3), penduletin (4), methyl 4-hydroxybenzoate (5), p-hydroxybenzoic acid (6), methyl 3,4-dihydroxybenzoate (7), 5-hydroxy-2-methoxybenzoic acid (8), vanillic acid (9) and 3,4-dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, Vitex agnus-castus. The structures of compounds 1-10 were identified with the help of spectroscopic techniques. Compounds 3-10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell-based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition.
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Article Synopsis
- * These compounds were characterized using various spectroscopic techniques and were tested against 13 microorganisms and soybean lipoxygenase to assess their antimicrobial and anti-inflammatory efficacy.
- * Results indicated strong antibacterial effects, particularly against ATCC 12453, with a minimum inhibitory concentration (MIC) of 31.125 µg/mL, and promising anti-LOX activity with IC values of 38.12 μM and 34.12 μM for the compounds.
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