Taste is the main sensory system that keeps a check on ingested food. Human beings are able to recognize five basic tastes: salty, sour, sweet, bitter and umami. Gustometry, including both gustometry with application of taste substances and electrogustometry, is the method of taste examination. There are various methods of applying taste substances during gustometry examination. The stimuli used in gustometry are: citric acid or hydrochloric acid (sour taste), caffeine or quinine hydrochloride (bitter taste), sodium chloride (salty taste), saccharose (sweet taste), monosodium glutamate (umami taste). Electrogustometry, widely used by clinicians to examine taste sensitivity, allows to estimate the functioning of taste by means of electric excitability thresholds determined through the response to the irritation of taste buds area with electrical current of different intensity. Electrogustometry is especially useful in estimating the efficiency of sensory pathways. However, if we want to examine taste sensitivity to individual taste categories we should use more laborious gustometry with the application of taste substances, which main advantage is the use of physiological stimuli.
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Radiother Oncol
January 2025
Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:
Background/purpose: Taste impairment is a common yet complex toxicity of head and neck cancer (HNC) radiotherapy treatment that may affect quality of life of survivors. This study aimed to predict acute and late taste impairment using taste bud bearing tongue mucosa as a new taste-specific organ-at-risk compared to full oral cavity as identified in previous studies.
Materials/methods: Included HNC patients were treated with curative radiotherapy between 2007 and 2022.
Neuroimage
January 2025
Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Introduction: The beneficial effects of substituting sugar with non-caloric sweeteners (NCSs) remain uncertain due to the mismatch between their rewarding sweet taste and lack of energy content. Functional magnetic resonance imaging (fMRI) studies indicate an influence of cognitive processes (e.g.
View Article and Find Full Text PDFFood Chem
January 2025
Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, İstanbul 34210, Türkiye; Health Biotechnology Joint Research and Application Center of Excellence, Istanbul 34903, Türkiye. Electronic address:
Umami taste properties of a novel octameric peptide KADEDSLA and its mutants p.A2G, p.D5E, and BMP (KGDEESLA, beef meaty peptide) were assessed by molecular docking, and molecular dynamics (MD) (>1 μsec), MM-PBSA, and Mutational Affinity Prediction (MAP) methods.
View Article and Find Full Text PDFPLoS Biol
January 2025
Department of Biology, University of Fribourg, Fribourg, Switzerland.
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