Colorectal carcinomas (CRCs) infiltrating through the muscularis propria layer without infiltration of adjacent structures, organs or the serosa-i.e. the pT3 tumors, compose the largest subset of large intestinal carcinomas treated by surgical resection. They are heterogeneous in terms of prognosis. CRCs treated by surgery in a period of 69 months were prospectively classified as pT3a tumors (invading to a maximum of 5 mm beyond the muscularis propria) and pT3b tumors (invading deeper). Their nodal status, incidence of vascular invasion and the presence or absence of distant metastases were analyzed in relation to the depth of invasion. Of the 593 CRCs primarily treated by surgery 429 were pT3 tumors. CRCs categorized as pT3a had significantly lower rates of nodal involvement (44% vs 75%), massive nodal involvement (pN2) (9% vs 39%), venous invasion (17% vs 30%) and distant metastasis (11% vs 28%) than pT3b tumors. Significant differences in these prognostic variables in pT3a and pT3b cancers were observed both for carcinomas of the colon and those of the rectum. Such differences were not obvious in further 66 ypT3 cases of rectal carcinoma receiving neoadjuvant treatment before surgery. Tumors in the pT3a category are associated with a better prognostic profile than pT3b tumors. This subdivision might be useful in both prognostication and treatment planning.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12253-009-9149-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-Risk Melanoma: Stage Before Operating.
Pigment Cell Melanoma Res
January 2025
Department of Plastic Surgery, Nottingham University Hospitals NHS FT, Nottingham, UK.
Current NICE guidelines state that in high-risk melanoma patients, imaging should not be offered before SLNB unless lymph node or distant metastases are suspected. Our experience has been that in patients with pT3b, pT4a and pT4b melanomas, the rate of management-changing findings on axial imaging prior to SLNB was high and that 'stage before operating' is a better approach. We now offer full axial imaging as staging to all high-risk melanoma patients prior to SLNB and advise other skin cancer MDTs to follow this approach.
View Article and Find Full Text PDFPatterns of failure with F-DCFPyL PSMA-PET/CT in the post-prostatectomy setting: A regional cohort analysis.
Can Urol Assoc J
October 2024
McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada.
Introduction: This study aimed to assess the detection rate of prostate cancer recurrence by prostate-specific member antigen positron emission tomography/computed tomography (PSMA PET/CT) with F-DCFPyL in patients with residual disease or biochemical recurrence (BCR), and its association with surgical pathology and prostate-specific antigen (PSA) kinetics.
Methods: Men from South Central Ontario enrolled in the PSMA Registry for Recurrent Prostate cancer (PREP) between April 2019 and December 2021 after radical prostatectomy (RP) and who had 1) pathologic stage N1 or persistent elevated PSA; or 2) BCR (PSA >0.10 ng/mL) where initial postoperative PSA was undetectable were included.
The clinical significance of elastic lamina invasion in patients with pStage II colorectal cancer: a notable prognostic indicator.
World J Surg Oncol
October 2024
Department of Surgery, Kurume University School of Medicine, Asahimachi- 67, Kurume-City, Japan.
Background: Some colorectal cancers (CRCs) are clinically diagnosed as cT4a with serosal invasion (SI). However, the cT4a is most often underdiagnosed pathologically as pT3 without SI by hematoxylin-eosin (H&E) staining alone. Using Elastica van Gieson (EVG) staining, some pT3 tumors invade the elastic lamina (EL), which extends just below the serosal layer.
View Article and Find Full Text PDFPredictors of biochemical recurrence after robot-assisted radical prostatectomy: single-centre analysis.
Cent European J Urol
February 2024
Department of Urology, Royal Surrey County Hospital, Guildford, Surrey, United Kingdom.
Article Synopsis
- The study analyzed risk factors for biochemical recurrence (BCR) after robot-assisted radical prostatectomy (RARP) using data from patients treated between 2018 and 2020, excluding those with certain complications or missing data.
- Results indicated that the International Society of Urological Pathologists (ISUP) grade is a strong predictor for BCR, particularly for higher grades, while pT3b stage also significantly predicted BCR in patients with advanced tumors.
- The findings conclude that ISUP grade and tumor stage are critical risk factors for BCR after RARP, with additional emphasis on the significance of positive surgical margins in pT2 cases and the pT3b substage in pT3 cases.
Risk of Biochemical Recurrence and Metastasis in Prostate Cancer Patients Treated with Radical Prostatectomy After a 10-year Disease-free Interval.
Eur Urol Oncol
September 2024
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, Koc University Hospital, Istanbul, Turkey. Electronic address:
Article Synopsis
- Prostate-specific antigen (PSA) testing is critical for monitoring prostate cancer patients after treatment, but there's uncertainty about PSA thresholds for identifying those at higher risk of biochemical recurrence (BCR).
- This study analyzed 4,639 prostate cancer patients who had undetectable PSA levels for at least 10 years post-surgery, finding that 5.2% later developed BCR, with some progressing to metastatic cancer.
- Key factors predicting late BCR included advanced tumor stage, Gleason score, and surgical margins, while age and initial PSA levels did not significantly predict outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!