Similar Publications

Acute severe ulcerative colitis: defining the precise moment for colectomy.

Expert Rev Gastroenterol Hepatol

January 2025

INFINY Institute, Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, Vandœuvre-lès-Nancy, France.

Introduction: Acute severe ulcerative colitis (ASUC) is a critical manifestation of ulcerative colitis (UC), often necessitating colectomy when medical management fails. Despite advancements in therapeutic interventions such as corticosteroids, biologics, and JAK inhibitors, a significant proportion of patients require surgery, with colectomy rates ranging from 10% to 15%.

Areas Covered: This paper reviews the factors influencing the timing and necessity of colectomy in ASUC management, emphasizing the importance of multidisciplinary decision-making involving gastroenterologists and surgeons.

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Basic Science and Pathogenesis.

Alzheimers Dement

December 2024

Janssen Research & Development, A Division of Janssen Pharmaceutica, Beerse, Belgium, Beerse, Belgium.

Background: Microglial cells have emerged as key players in the pathogenesis of Alzheimer's disease (AD). They act as a first line defense and fulfil a crucial role during brain development and circuit homeostasis. Microglia are involved in the removal of debris, control neural activity, regulate synaptic plasticity, and synapse pruning.

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Background: The Alzheimer's Association recommends early screening of Alzheimer's disease and related dementias(ADRD), urging the development of biomarkers and other tools for early risk/detection. However, the general public's willingness to be tested for early ADRD must be considered, particularly among minoritized populations. For example, Black older adults within the United States (U.

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Background: Present challenges in (Dutch) mental health care touch upon the core of the social contract between the profession and society. This urges an explicit account of professionalism in psychiatry.

Aim: To present an integral model of medical professionalism in psychiatry.

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Recommendations stress tracing and respecting links between communities and animal remains such as bones.

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