AI Article Synopsis
- Glycosyltransferases have unique substrate specificities, making their engineering a crucial area of research.
- The study successfully introduced new activity into a glycosyltransferase linked to the production of landomycin E.
- This was accomplished by identifying key amino acids that play a significant role in determining the substrate specificity of glycosyltransferases.
Article Abstract
As glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field. In this work, we were able to introduce an activity into a glycosyltransferase involved in natural product (landomycin E) biosynthesis. This was achieved by recognizing hot spot amino acids in glycosyltransferases which are strongly involved in determining substrate specificity.
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| http://dx.doi.org/10.1016/j.chembiol.2008.12.003 | DOI Listing |
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