Resistance to currently available antibiotics has become a widely recognized crisis in the medical community. To address this, many companies and researchers are refocusing their attention towards natural products, which have an excellent track record of producing effective antibacterial drugs. The AMRI natural product library was screened for activity against multi-drug resistant Staphylococcus aureus (MDRSA). The active samples were counter screened for cytotoxicity against the human hepatocellular carcinoma HepG2 cell line to determine an in vitro therapeutic index (in vitro TI). Those samples with a high in vitro TI were selected for fractionation and dereplication. This led to the discovery of a new anthracycline structure. This metabolite, named mutactimycin E (1), exhibited moderate activity against several gram positive organisms. Here we report the isolation, structure elucidation and biological activities of this new compound.
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Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert.
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Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, UK.
Bacteria belonging to the phylum are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling.
View Article and Find Full Text PDFMutactimycin E, a new anthracycline antibiotic with gram-positive activity.
J Antibiot (Tokyo)
November 2008
AMRI, Bothell Research Center, Bothell, WA 98011, USA.
Resistance to currently available antibiotics has become a widely recognized crisis in the medical community. To address this, many companies and researchers are refocusing their attention towards natural products, which have an excellent track record of producing effective antibacterial drugs. The AMRI natural product library was screened for activity against multi-drug resistant Staphylococcus aureus (MDRSA).
View Article and Find Full Text PDFMutactimycin PR, a new anthracycline antibiotic from Saccharothrix sp. SA 103. II. Physico-chemical properties and structure elucidation.
J Antibiot (Tokyo)
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Ecole Nationale Supérieure d'Agronomie de Toulouse, INPT, Laboratoire de Génie Chimique, UMR 5503 (CNRS/INPT/UPS), 1, avenue de l'Agrobiopôle, B.P. 107, F-31 326 Castanet-Tolosan Cedex, France.
A new antibiotic termed mutactimycin PR (1) was isolated along with the known mutactimycin C (2) from the fermentation broth of Saccharothrix sp. SA 103. The two compounds belong to the anthracycline group.
View Article and Find Full Text PDFMutactimycin PR, a new anthracycline antibiotic from Saccharothrix sp. SA 103. I. Taxonomy, fermentation, isolation and biological activities.
J Antibiot (Tokyo)
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Ecole Nationale Supérieure d'Agronomie de Toulouse, INPT, Laboratoire de Génie Chimique, UMR 5503 (CNRS/INPT/UPS), 1, avenue de l'Agrobiopôle, B.P. 107, F-31 326 Castanet-Tolosan Cedex, France.
In the course of screening for new antibacterial agents, a new isolate collected from a soil sample of an arid area in south Algeria, produced a red pigment which was shown an antagonistic action against a gram-positive bacterium Bacillus subtilis. The isolate was identified as Saccharothrix sp. and named SA 103.
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Institute of Organic Chemistry, Göttingen, Germany.
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy.
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