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Fucoidan from Apostichopus japonicus enhances intestinal barrier function and promotes intestinal immunity via regulating the gut microbiota and tryptophan metabolism.
Int J Biol Macromol
January 2025
State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, China. Electronic address:
Apostichopus japonicus is one of the most popular types of sea cucumber among consumers in Southeast Asia. Fucoidan from Apostichopus japonicus (Aj-FUC) has attracted considerable attention because of its immunomodulatory activities. Aj-FUC is indigestible in the human upper gastrointestinal tract but can be utilized by the gut microbiota.
View Article and Find Full Text PDFModulatory action of Bryonia alba on the immune system in cyclophosphamide induced immunosuppression in BALB/c mice.
PLoS One
December 2024
Drug Standardization, Central Council for Research in Homoeopathy, New Delhi, India.
Article Synopsis
- Oxidative stress and inflammation are key issues in immune-compromised diseases and cancer treatments, prompting a study on the immune-boosting effects of Bryonia alba (BA) in mice with induced immune deficiency.
- The research involved treating BALB/c mice with various potencies of BA after cyclophosphamide administration, resulting in significant improvements in immune parameters like RBC and WBC levels, and increased expression of important immune cytokines.
- Histopathology showed that BA-treated mice maintained healthy spleen structures compared to those damaged by cyclophosphamide, suggesting BA's potential as an effective immunostimulant during chemotherapy, but more studies are needed on its effects against immune-compromised infections.
Multi-omics reveals the mechanism of Sparassis latifolia polysaccharides to relieve cyclophosphamide-induced immune injury in liver of mice.
Int J Biol Macromol
December 2024
College of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, China. Electronic address:
The present study aimed to investigate the impact of Sparassis latifolia polysaccharides (SLPs) on hepatic immune function in cyclophosphamide (CTX)-induced immunocompromised mice. Our findings demonstrated that SLPs effectively suppressed the production of alanine aminotransferase (ALT), aspartate aminotransferase (AST), inflammatory factors, and acute phase proteins, while improving the hepatic oxidative stress state. Additionally, SLPs exerted inhibitory effects on inflammatory cell infiltration within hepatic tissue.
View Article and Find Full Text PDFPolysaccharides from Yupingfeng granules ameliorated cyclophosphamide-induced immune injury by protecting intestinal barrier.
Int Immunopharmacol
January 2025
Sinopharm Group Guangdong Medi-World Pharmaceutical Co., Ltd., Guangzhou, China.
Immune injury is the main side effect caused by cyclophosphamide and the disruption of the intestinal barrier may be an important cause. Yupingfeng granules have been reported to have immunomodulatory effects and polysaccharides are important components of them. This study aimed to investigate the ameliorative effect of polysaccharides from Yupingfeng granules (YPFP) on cyclophosphamide induced immune injury and reveal their potential mechanisms based on its protective effect on the intestine.
View Article and Find Full Text PDFFecal Microbiota Transplantation Activity of Polysaccharides and Their Protective Effect on Cyclophosphamide-Induced Immunosuppression and Intestinal Injury in Mice.
Foods
November 2024
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China.
polysaccharides (FLP1s) have potential biological activities. Our previous study showed that FLP1s positively regulated gut immunity and microbiota. However, it is still unclear whether FLP1s mediate gut microbiota in immunosuppressed mice.
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