Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Bioorg Med Chem Lett

Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 8 Clarke Drive, Cranbury, NJ 08512, USA.

Published: February 2009

Synthesis and SAR of para-alkylthiophenoxyacetic acids is described. Achiral compounds 30, 31 and 32 were identified as potent and selective PPARdelta agonists.

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http://dx.doi.org/10.1016/j.bmcl.2008.12.113DOI Listing

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