AI Article Synopsis
- A renal transplant patient developed unique anti HLA-DP antibodies before showing signs of chronic humoral rejection.
- The patient's immune response included not only donor-specific but also non-donor-specific DP antigens, all sharing the same amino-acid sequence.
- This case suggests that matching epitopes, rather than just HLA antigens, might be more effective in preventing rejection in organ transplants.
Article Abstract
We report the case of a renal transplanted patient, in whom the detection of a unique anti HLA-DP antibody response preceded the development of chronic humoral rejection. In addition to donor-specific anti-DP alloantibodies, the patient displayed reactions against several non-donor-specific DP antigens (NDSA). Interestingly, we found that all the DP molecules recognized by the alloantibodies displayed the same amino-acid sequence suggesting that epitope sharing between unrelated HLA molecules was the mechanism underlying NDSA generation. This case highlights the pathogenicity of anti-DP alloantibodies and suggests that it could be more meaningful to match the epitopes than the HLA antigens for the prevention of rejection.
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| http://dx.doi.org/10.1016/j.trim.2008.12.006 | DOI Listing |
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