[A multi-chamber model of quartz dust kinetics in the pulmonary region during chronic inhalation exposure in rats].

The contributors propose a multichamber model for the assessment of dust particles' concentration, elimination and translocation in deep pulmonary zones. The choice of the model structure is dominated by the following criteria: that dust penetration into the interstitial pulmonary tissues and its translocation to the lymph nodes can be performed by non-phagocytized particle only; that these processes depend on the degree of dust-induced lesions in the macrophages and the growth of compensating neutrophilic phagocytosis; that part of the penetrating particles would continuously return to the free surface of the pulmonary zone together with the mobilized interstitial lung macrophages. The model adequately corresponds to the experimental data obtained in prolonged inhalation experiments, and imitates the kinetic effects related to severe damages and protection of the pulmonary clearance macrophage mechanisms.