One hundred fifty AAC(6')-Ib-positive gram-negative isolates collected between 1981 and 1991 were examined by PCR for the presence of the aac(6')-Ib-cr variant and other plasmid-mediated quinolone resistance (PMQR) genes. None had the aac(6')-Ib-cr variant, qnrA, qnrS, qnrC, or qepA, but two strains collected in 1988 had qnrB alleles, making these the earliest known PMQR genes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663075 | PMC |
| http://dx.doi.org/10.1128/AAC.01447-08 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of Efflux Pump Contributions and Plasmid-Mediated Genetic Determinants in Ciprofloxacin-Resistant .
Pathogens
December 2024
College of Public Health, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
This study aimed to explore the interactions among genetic determinants influencing ciprofloxacin resistance in . Treatment with PAβN, an efflux pump inhibitor, resulted in a 4-32-fold reduction in the minimum inhibitory concentration (MIC) across all 18 ciprofloxacin-resistant isolates. Notably, isolates without point mutations reverted from resistance to sensitivity.
View Article and Find Full Text PDFPresence of qnr and aac(6́)-Ib-cr Genes among Quinolone Resistant Proteus species Isolates at Mymensingh, Bangladesh.
Mymensingh Med J
January 2025
Dr Parvez Arafa, Lecturer, Department of Virology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:
Article Synopsis
- Fluroquinolone resistance in Enterobacteriaceae, including Proteus, poses a significant public health threat, particularly affecting treatments for UTIs and intra-abdominal infections.
- The study aimed to identify specific quinolone resistance genes in ciprofloxacin-resistant Proteus species within a defined timeframe and location in Bangladesh.
- Results showed a high prevalence (64.58%) of plasmid-mediated quinolone resistance genes among resistant isolates, indicating a concerning trend that could lead to increased resistance and transmission due to over-prescription of fluoroquinolones.
Prevalence of Plasmid-Mediated Quinolone Resistance Genes in Isolates From Colonic Biopsies of Iranian Patients With Inflammatory Bowel Diseases: A Cross-Sectional Study.
Health Sci Rep
December 2024
Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences Tehran Iran.
Background And Aims: Emerging evidence suggests that ciprofloxacin and other quinolones can be effectively used as adjuncts to immunosuppressive therapy in managing inflammatory bowel disease (IBD). Clinical isolates of Enterobacterales frequently exhibit quinolone resistance. Additionally, increased IBD severity has been linked to the proliferation of Enterobacterales in the gut.
View Article and Find Full Text PDFOccurrence of Plasmid-Mediated Quinolone Resistance and Carbapenemase-Encoding Genes in Isolates from Nosocomial Patients in Aguascalientes, Mexico.
Pathogens
November 2024
Laboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes 20100, Mexico.
is a leading cause of healthcare-associated infections, which are related to substantial morbidity and mortality. The incidence of Plasmid-Mediated Quinolone Resistance (PMQR) determinants has been previously reported in this bacterium. However, there is limited information regarding the presence of PMQR and carbapenemase-encoding genes simultaneously.
View Article and Find Full Text PDFMolecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
Sci Rep
November 2024
Faculty of Medicine of Tunis - LR99ES09 Research Laboratory «Antimicrobial resistance», University of Tunis El Manar, 1007, Tunis, Tunisia.
Article Synopsis
- Fluoroquinolone-resistant (FQs-R) E. coli from patients undergoing prostate biopsies are increasingly common, raising concerns about using FQs for infection prevention.
- A study between 2016 and 2018 found that 61.06% of patients carried FQs-R Enterobacterales, primarily E. coli, with varying resistance profiles linked to specific genetic mutations.
- The research highlighted that these resistance mechanisms, including mutations in the gyrA and parC genes as well as certain plasmid-mediated resistance genes, significantly elevate the Minimum Inhibitory Concentrations (MICs), posing a risk for post-procedure infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!