An excitation dependent rotating frame of reference to observe the magnetic resonance phenomenon is introduced in this paper that, to the best of our knowledge, has not been used previously in the nuclear magnetic resonance context. The mathematical framework for this new rotating frame of reference is presented based on time scaling the Bloch equation after transformation to the classical rotating frame of reference whose transverse plane is rotating at the Larmor frequency. To this end, the Bloch equation is rewritten in terms of a magnetisation vector observed from the excitation dependent rotating frame of reference. The resultant Bloch equation is referred to as the time scaled Bloch equation. In the excitation dependent rotating frame of reference whose coordinates are rotating at the instantaneous Rabi frequency the observed magnetisation vector is a much slower signal than the true magnetisation in the rotating frame of reference. As a result the ordinary differential equation solvers have the ability to solve the time scaled version of the Bloch equation with a larger step size resulting in a smaller number of samples for solving the equation to a desired level of accuracy. The simulation results for different types of excitation are presented in this paper. This method may be used in true Bloch simulators in order to reduce the simulation time or increase the accuracy of the numerical solution. Moreover, the time scaled Bloch equation may be employed to determine the optimal excitation pattern in magnetic resonance imaging as well as designing pulses with better slice selectivity which is an active area of research in this field.
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http://dx.doi.org/10.1109/IEMBS.2008.4650525 | DOI Listing |
Int J Mol Sci
December 2024
Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.
ORF2p (open reading frame 2 protein) is a multifunctional multidomain enzyme that demonstrates both reverse transcriptase and endonuclease activities and is associated with the pathophysiology of cancer. The 3D structure of the entire seven-domain ORF2p complex was revealed with the recent achievements in structural studies. The different arrangements of the CTD (carboxy-terminal domain) and tower domains were identified as the "closed-ring" and "open-ring" conformations, which differed by the hairpin position of the tower domain, but the structural diversity of these complexes has the potential to be more extensive.
View Article and Find Full Text PDFBiomed Eng Lett
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NaviNetics, Inc, Rochester, MN USA.
Stereotactic systems have traditionally used Cartesian coordinate combined with linear algebraic mathematical models to navigate the brain. Previously, the development of a novel stereotactic system allowed for improved patient comfort, reduced size, and carried through a simplified interface for surgeons. The system was designed with a work envelope and trajectory range optimized for deep brain stimulation applications only.
View Article and Find Full Text PDFPLoS Comput Biol
January 2025
Department of Engineering Management, University of Antwerp, Antwerp, Belgium.
Self-motion is an essential but often overlooked component of sound localisation. As the directional information of a source is implicitly contained in head-centred acoustic cues, that acoustic input needs to be continuously combined with sensorimotor information about the head orientation in order to decode to a world-centred frame of reference. When utilised, head movements significantly reduce ambiguities in the directional information provided by the incoming sound.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Antal Bejczy Center for Intelligent Robotics, Obuda University, 1034 Budapest, Hungary.
This paper presents a robust and efficient method for validating the accuracy of orientation sensors commonly used in practical applications, leveraging measurements from a commercial robotic manipulator as a high-precision reference. The key concept lies in determining the rotational transformations between the robot's base frame and the sensor's reference, as well as between the TCP (Tool Center Point) frame and the sensor frame, without requiring precise alignment. Key advantages of the proposed method include its independence from the exact measurement of rotations between the reference instrumentation and the sensor, systematic testing capabilities, and the ability to produce repeatable excitation patterns under controlled conditions.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Orthopaedic and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, Ludwig Maximilians University Munich, Munich, Germany.
In modern knee arthroplasty, surgeons increasingly aim for individualised implant selection based on data-driven decisions to improve patient satisfaction rates. The identification of an implant design that optimally fits to a patient's native kinematic patterns and functional requirements could provide a basis towards subject-specific phenotyping. The goal of this study was to achieve a first step towards identifying easily accessible and intuitive features that allow for discrimination between implant designs based on kinematic data.
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