Contraction and half relaxation times are important temporal measures of the physiological state of the muscle. We hypothesize that mouse button click durations may mirror muscle twitch contraction times (contraction time + half relaxation time). When comparing muscle twitch contraction times and mouse button-click durations between children, adult females and adult males only small differences in muscle twitch contraction times were observed across these groups whereas large differences in mouse button click durations were measured. Currently, computer mice are designed using a 'one size fits all' approach and the results indicate that computer mouse button activation force has different effects on children, adult females and adult males, thus pointing towards effects of device design on computer mouse operation. The results indicate that it may be possible to evaluate the appropriateness of input device activation forces for different statured users by seeking activation forces where the mouse button-click durations approximate and approach the durations of involuntary muscle twitches.
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http://dx.doi.org/10.1109/IEMBS.2008.4649657 | DOI Listing |
Aging negatively affects the capacity of muscle stem cells (MuSCs) to regenerate muscle. In this issue of the JCI, Ancel, Michaud, and colleagues used a high-content imaging screen to identify nicotinamide and pyridoxine as promoters of MuSC function. The combination of the two compounds promoted MuSC function in vivo in aged mice and in primary cells isolated from older individuals.
View Article and Find Full Text PDFClin Transl Med
October 2024
Department of Cancer Biology & Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California, USA.
Background: In a previously reported Phase I trial, we observed therapy-associated declines in circulating myeloid-derived suppressor cells (MDSCs) with the administration of white button mushroom (WBM) tablets in prostate cancer (PCa) patients. These observations led us to hypothesise that WBM could mitigate PCa progression by suppressing MDSCs.
Methods: We performed bidirectional translational research to examine the immunomodulatory effects of WBM consumption in both syngeneic murine PCa models and patients with PCa participating in an ongoing randomised Phase II trial (NCT04519879).
Psychopharmacology (Berl)
October 2024
Laboratory of Neurobiology and Neurobiotechnology, Department of Biological Sciences, School of Sciences, Humanities and Languages of the São Paulo State University (Unesp), Assis, São Paulo, 19806-900, Brazil.
Rationale: Despite the existing anatomical and physiological evidence pointing to the involvement of orexinergic projections from the lateral hypothalamus (LH) in regulating fear-related responses, little is known regarding the contribution of the orexin system in the prelimbic cortex (PL) on contextual fear.
Objectives: We investigated the role of orexin-A (Orx) and orexin type 1 receptors (OrxR) in the PL during the expression of contextual conditioned fear in mice.
Methods: Neural tract tracing of the LH-PL pathway and OrxR immunoreactivity in the PL of C57BL/6 male mice were performed.
Braz J Biol
October 2024
Universidade Federal de Mato Grosso do Sul - UFMS, Centro de Estudos em Células-Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Faculdade de Medicina, Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Campo Grande, MS, Brasil.
Nat Commun
September 2024
Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea.
Post-surgical adhesions frequently occur after intra-abdominal surgery, leading to severe complications. Despite the development of various types of adhesion barriers to address post-surgical adhesions, several limitations persist, including off-target localization, handling difficulties, and potential immunogenicity. Here, we report a spray-type adhesion barrier for broad, fast application, forming two sequential networks.
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