The CT uroscan contains three to four time-spaced acquisitions of the same patient. Registration of these acquisitions forms a vectorial volume, which contains a more complete anatomical information. In order to outline the anatomical structures, multi-dimensional classification is necessary for analyzing this vectorial volume. Because of the partial volume effect (PVE), probability distributions are assigned to the different material types within this vectorial volume instead of a definite material distribution. Gaussian mixture model is often used in probability classification problems to model such distributions, but it relies only on the intensity distributions, which will lead a misclassification on the boundaries and inhomogeneous regions with noises. In order to solve this problem, a neighborhood weighted Gaussian mixture model is proposed in this paper. Expectation Maximization algorithm is used as optimization method. The experiments demonstrate that the proposed method can get a better classification result and less affected by the noise.
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http://dx.doi.org/10.1109/IEMBS.2008.4649563 | DOI Listing |
Sci Rep
January 2025
BioResource Research Center, RIKEN, 3-1-1, Koyadai, Tsukuba, 305-0074, Ibaraki, Japan.
Omics data provide a plethora of quantifiable information that can potentially be used to identify biomarkers targeting the physiological processes and ecological phenomena of organisms. However, omics data have not been fully utilized because current prediction methods in biomarker construction are susceptible to data multidimensionality and noise. We developed OmicSense, a quantitative prediction method that uses a mixture of Gaussian distributions as the probability distribution, yielding the most likely objective variable predicted for each biomarker.
View Article and Find Full Text PDFTau exhibits change in both spatial extent and density of pathology along the Alzheimer's disease (AD) spectrum with each aspect contributing to the overall burden of pathological tau. Nevertheless, studies using Tau PET have measured either magnitude using standardized uptake value ratios (SUVRs) or extent using number of Tau+ regions. We hypothesized that combining these two dimensions into a single measure of Magnitude and eXtent, Tau-MaX, would provide improved quantification of global tau burden as well as allowing for a region-agnostic measure of global tau burden that does not require a pre-specified region of interest (ROI) or meta-ROI.
View Article and Find Full Text PDFStat Med
February 2025
Department of Statistics, University of Connecticut, Storrs, Connecticut.
The use of mixed-effect models to understand the evolution of the human immunodeficiency virus (HIV) and the progression of acquired immune deficiency syndrome (AIDS) has been the cornerstone of longitudinal data analysis in recent years. However, data from HIV/AIDS clinical trials have several complexities. Some of the most common recurrences are related to the situation where the HIV viral load can be undetectable, and the measures of the patient can be registered irregularly due to some problems in the data collection.
View Article and Find Full Text PDFBiophys Chem
January 2025
Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata 700106, India. Electronic address:
Quantitative characterization of protein conformational landscapes is a computationally challenging task due to their high dimensionality and inherent complexity. In this study, we systematically benchmark several widely used dimensionality reduction and clustering methods to analyze the conformational states of the Trp-Cage mini-protein, a model system with well-documented folding dynamics. Dimensionality reduction techniques, including Principal Component Analysis (PCA), Time-lagged Independent Component Analysis (TICA), and Variational Autoencoders (VAE), were employed to project the high-dimensional free energy landscape onto 2D spaces for visualization.
View Article and Find Full Text PDFSensors (Basel)
January 2025
InViLab, Department of Electromechanical Engineering, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.
Laser-based systems, essential in diverse applications, demand accurate geometric calibration to ensure precise performance. The calibration process of the system requires establishing a reliable relationship between input parameters and the corresponding 3D description of the outgoing laser beams. The quality of the calibration depends on the quality of the dataset of measured laser lines.
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