This study provides cuffless and non-invasive technique of Systolic Blood Pressure (SBP) estimation by using only a Photoplethysmography (PPG) sensor. As people get older, cardiovascular peculiarities are changing more and more, so this study focuses on the presumption of SBP in old age. Ages 60 and over were defined as old age and grouped into an aged class in this study, ages fewer than 60 were grouped into a young-middle class. The measured data in this experiment were both Capacity Pulse Wave (PW) and SBP. PW was obtained by the PPG and SBP was obtained by the commercial Blood Pressure (BP) meter with a cuff. Then the regression equation of SBP was calculated from individual information and features of PW. 96 healthy volunteers participated in the BP and PW measurement experiment. This result implied that patients' cardiovascular peculiarities change according to aging and vary among difference individuals. Furthermore, the data of old age were classified into four classes through a boundary values that depend on b and d of Acceleration Pulse Wave (APW). As regards the result of the aged class, the measured SBP was significantly correlated with the presumed SBP (r=0.89, SD=8.2mmHg) and the SD was 5.5 mmHg better than the SD of non-classified data. In conclusion, it is quite important for SBP estimation to divide data into several classes by age. Besides, the classification by using the parameters with the features of APW as individual cardiovascular peculiarities is a hopeful technique for the aged class. Therefore, the proposed techniques are quite promising and useful for the feature studies on cuffless and continuous BP monitoring.
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http://dx.doi.org/10.1109/IEMBS.2008.4649409 | DOI Listing |
J Neuroinflammation
January 2025
Department of Neuroscience and Experimental Therapeutics, School of Medicine, Texas A&M Health Science Center, Bryan, TX, 77807-3260, USA.
Background: Disturbances of the sleep-wake cycle and other circadian rhythms typically precede the age-related deficits in learning and memory, suggesting that these alterations in circadian timekeeping may contribute to the progressive cognitive decline during aging. The present study examined the role of immune cell activation and inflammation in the link between circadian rhythm dysregulation and cognitive impairment in aging.
Methods: C57Bl/6J mice were exposed to shifted light-dark (LD) cycles (12 h advance/5d) during early adulthood (from ≈ 4-6mo) or continuously to a "fixed" LD12:12 schedule.
Neurosurg Rev
January 2025
Department of Orthopaedics, Peking University Third Hospital, Beijing, China.
The combination of congenital C1 occipitalization and C2-3 non-segmentation (i.e. "sandwich fusion") results in early development of atlantoaxial dislocation (AAD).
View Article and Find Full Text PDFBMJ Open
January 2025
Amsterdam Public Health research institute, Amsterdam, The Netherlands.
Objectives: Knowledge about the long-term course and prognosis of persistent somatic symptoms (PSS) is important to improve clinical decision-making and guidance for patients with PSS. Therefore, we aimed to: (1) identify distinct 5-year trajectories of symptom severity, physical and mental functioning in adult patients with PSS and (2) explore patient characteristics associated with these trajectories.
Design: We used longitudinal data (seven measurements over a 5-year period) of the PROSPECTS study: a prospective cohort of adult patients with PSS.
Korean J Intern Med
January 2025
Department of Respiratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Background/aims: Chronic obstructive pulmonary disease (COPD) management guidelines have increasingly emphasised the importance of exacerbation prevention, and the role of blood eosinophil count (BEC) as a biomarker for inhaled corticosteroids (ICS) response. This study aimed to describe the distribution and stability of BEC and understand real-world treatment patterns among COPD patients in South Korea.
Methods: This was a retrospective database analysis using data obtained from the KOrea COPD Subgroup Study (KOCOSS) registry between January 2012 and August 2018.
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