AI Article Synopsis
- The dynamic clonal selection immune clustering algorithm is based on clonal selection immune principles and hierarchical clustering without requiring prior knowledge.
- The algorithm utilizes antibody affinity for antigen recognition and dynamically adjusts mutation rates, impacting antibody locations as evolution progresses.
- Experimental results indicate that this new algorithm achieves better clustering accuracy and overall performance compared to traditional clustering methods.
Article Abstract
According to the basis of clonal selection immune algorithm and hierarchical clustering, a dynamic clonal selection immune clustering algorithm is presented, which no pre-knowledge is needed. The proposed algorithm bases on antibody affinity, to recognize antigen, restrain and merge antibody. By using aiNET immune network model, the algorithm mutates location of antibodies, in which the mutating rate is dynamically adjusted with inverse proportion to the number of immune evolution generations. After dynamic mutation, the similar antibodies are merged again, and the same processes repeats until it meets the ending condition. Experimental results showed that the proposed algorithm is more coincidental reality of clustering and more preferable performance than traditional ones.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/IEMBS.2008.4649339 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Boston Children's Hospital, Boston, MA, USA.
Background: Alzheimer's disease (AD), an age-associated neurodegenerative disorder, is characterized by progressive neuronal loss and the accumulation of misfolded proteins such as amyloid-β and tau. While neuroinflammation, mediated by microglia and brain-resident macrophages, plays a pivotal role in AD pathogenesis, the intricate interactions among age, genes, and other risk factors remain elusive. Somatic mutations, known to accumulate with age, instigate clonal expansion across diverse cell types, impacting both cancer and non-cancerous conditions.
View Article and Find Full Text PDFCancer immune evasion, immunoediting and intratumour heterogeneity.
Nat Rev Immunol
January 2025
Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA, USA.
Cancers can avoid immune-mediated elimination by acquiring traits that disrupt antitumour immunity. These mechanisms of immune evasion are selected and reinforced during tumour evolution under immune pressure. Some immunogenic subclones are effectively eliminated by antitumour T cell responses (a process known as immunoediting), which results in a clonally selected tumour.
View Article and Find Full Text PDFRole of sclerostin in mastocytosis bone disease.
Sci Rep
January 2025
Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Staszica Street 11, 20-081, Poland.
Mastocytosis is a heterogeneous group of disorders, characterized by accumulation of clonal mast cells which can infiltrate several organs, most often spine (70%). The pathogenesis of mastocytosis bone disease is poorly understood. The main aim of the study was to investigate whether neoplastic mast cells may be the source of sclerostin and whether there is an association between sclerostin and selected bone remodeling markers with mastocytosis related bone disease.
View Article and Find Full Text PDFClinical and microbiological analyses of colistin-resistant strains among carbapenem-resistant complex clinical isolates.
Microbiol Spectr
December 2024
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Carbapenem-resistant complex (CR-ECC), which is rapidly increasing as the cause of nosocomial infections, has limited treatment options. The aim of this study is to investigate the microbiological and clinical traits and molecular epidemiology of isolates of CR-ECC and provide guidance for antibiotic selection in clinical practice. Clinical CR-ECC isolates (ertapenem MIC ≥ 2 mg/L) were collected from 2021 to 2022.
View Article and Find Full Text PDFDiploid inbred-based hybrids: fast-forward breeding approach in potatoes.
Physiol Mol Biol Plants
December 2024
ICAR-Central Potato Research Institute, Bemloi, Shimla, Himachal Pradesh 171001 India.
Following the identification of the self-compatibility gene () in diploid potatoes two decades ago, the breeding of inbred based diploid hybrid potatoes made its way. Tetraploid potatoes have a long history of cultivation through domestication and selection. Tetrasomic inheritance, heterozygosity and clonal propagation complicate genetic studies, resulting in a low genetic gain in potato breeding.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!