AI Article Synopsis
- - The study focused on creating a stable nanoemulsion of citronella oil using high-pressure homogenization with varying amounts of surfactant and glycerol, finding optimal conditions at 2.5% surfactant and 100% glycerol for transparency and stability.
- - Glycerol improved the emulsion's appearance and stability due to its properties as a co-solvent and thickening agent, which helped retain more oil in smaller droplets.
- - The release of citronella oil from the nanoemulsion was influenced by droplet size and the concentrations of surfactant and glycerol, with higher concentrations leading to slower release rates that positively correlated with longer mosquito protection times.
Article Abstract
Encapsulated citronella oil nanoemulsion prepared by high pressure homogenization at varying amounts of surfactant and glycerol, was studied in terms of the droplet size, stability, release characteristics and in vivo mosquito protection. Transparent nanoemulsion can be obtained at optimal concentration of 2.5% surfactant and 100% glycerol. Physical appearance and the stability of the emulsion were greatly improved through an addition of glycerol, owing to its co-solvent and highly viscous property. The increasing emulsion droplet increased the oil retention. The release behavior could be attributed to the effect of droplet size and concentrations of surfactant and glycerol. By fitting to Higuchi's equation, an increase in glycerol and surfactant concentrations resulted in slow release of the oil. The release rate related well to the protection time where a decrease in release rate can prolong mosquito protection time.
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| http://dx.doi.org/10.1016/j.ijpharm.2008.12.029 | DOI Listing |
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