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Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study.
Can J Kidney Health Dis
January 2025
Division of Nephrology, Department of Medicine, Ottawa Hospital, University of Ottawa, ON, Canada.
Background: Patients with end-stage kidney disease (ESKD) have high rates of gastrointestinal bleeding due to several risk factors including platelet dysfunction, comorbid illness, and use of antiplatelet medications. Proton pump inhibitors (PPIs) reduce gastrointestinal bleeding and are recommended for high-risk patients such as those prescribed dual antiplatelet therapy (DAPT). Whether inappropriate duration of DAPT therapy and/or lack of appropriate PPI use contribute to the known elevated risk of gastrointestinal bleeding in hemodialysis patients is not known.
View Article and Find Full Text PDFDe Novo Hypercalcaemia in a Patient With Chronic Hypoparathyroidism.
Cureus
December 2024
Endocrinology, Mallow General Hospital/University College Cork, Cork, IRL.
Calcium Homeostasis in the human body is regulated by hormones, including parathyroid hormone and vitamin D3. Dysfunction in the form of hypoparathyroidism causes hypocalcaemia. In patients treated for primary hypoparathyroidism with activated vitamin D replacement, iatrogenic hypercalcaemia can occur.
View Article and Find Full Text PDFThe impacts of 2,4-D herbicide DMA® 4 IVM on reproductive health and gene expression along the hypothalamic-pituitary-gonad-liver [HPGL] axis in the fathead minnow (Pimephales promelas).
Chemosphere
December 2024
Aquatic Science Center, Wisconsin Sea Grant, University of Wisconsin - Madison, Madison, WI, USA. Electronic address:
Aquatic herbicides are commonly used to control a variety of non-native plants. One common active ingredient used in commercial herbicide formulations globally is 2,4-dichlorophenoxyacetic acid (2,4-D). Though 2,4-D is used in aquatic ecosystems, no studies have investigated cellular, biochemical, and transcriptional effects or mechanisms of 2,4-D exposure on fathead minnows (Pimephales promelas) throughout juvenile development.
View Article and Find Full Text PDFThe prevalence and factors associated with potentially inappropriate medications in Chinese older outpatients with heart failure.
BMC Geriatr
December 2024
Department of Pharmacy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Background: Potentially inappropriate medications (PIMs) can lead to adverse outcomes. This study aimed to investigate the prevalence of PIMs in older Chinese outpatients with heart failure according to the 2019 Beers criteria and the factors associated with PIMs.
Methods: A cross-sectional retrospective study was conducted using electronic medical data during January 1, 2020 to December 31, 2020 from 9 tertiary medical institutions in Chengdu, China.
Efficacy of transdermal ketoprofen on surgical inflammation in dogs.
Res Vet Sci
December 2024
School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia. Electronic address:
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in dogs. Despite having effective analgesic efficacy, prolonged oral administration has been associated with adverse effects. Transdermal delivery of ketoprofen has reduced the incidence of adverse effects in humans and could potentially be used in veterinary clinical medicine.
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