Objective: To establish a new method for evaluating quality stability of Shudihuang decoction pieces with near-infrared spectrum.

Method: Clustering analysis was used to distinguish different Shudihuang samples. And comparisons between NIR and HPLC fringerprint.

Result: Results of clustering reflected the similar degree among these samples. Compared with HPLC fingerprint, NIR analytical process fast and convenient with exact results.

Conclusion: NIR is a feasible and effective approach to examine the quality stability of Shudihuang decoction pieces with unique virtues.

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