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Influence of constant lightning on liver health: an experimental study.
Environ Sci Pollut Res Int
November 2022
A.P. Avtsyn Research Institute of Human Morphology, Moscow, Russian Federation.
Light pollution has become a serious problem in many urbanized areas of the world. The impact of prolonged exposure to light and consequent disruption of natural circadian rhythms has significant health implications. The current study was undertaken to evaluate the effect of prolonged exposure to light, simulating urban light pollution, on liver health.
View Article and Find Full Text PDFPhase II Trial of Chemopreventive Effects of Levonorgestrel on Ovarian and Fallopian Tube Epithelium in Women at High Risk for Ovarian Cancer: An NRG Oncology Group/GOG Study.
Cancer Prev Res (Phila)
June 2019
Cancer Prevention and Control, University of Arizona Cancer Center, Phoenix, Arizona.
A large body of epidemiologic evidence has shown that use of progestin-containing preparations lowers ovarian cancer risk. The purpose of the current study was to gather further preclinical evidence supporting progestins as cancer chemopreventives by demonstrating progestin-activation of surrogate endpoint biomarkers pertinent to cancer prevention in the genital tract of women at increased risk of ovarian cancer. There were 64 women enrolled in a multi-institutional randomized trial who chose to undergo risk-reducing bilateral salpingo-oophorectomy (BSO) and to receive the progestin levonorgestrel or placebo for 4 to 6 weeks prior to undergoing BSO.
View Article and Find Full Text PDFDual action of high estradiol doses on MNU-induced prostate neoplasms in a rodent model with high serum testosterone: Protective effect and emergence of unstable epithelial microenvironment.
Prostate
June 2017
Department of Biology, Laboratory of Microscopy and Microanalysis, Institute of Biosciences, Humanities and Exact Sciences-IBILCE, UNESP-Sao Paulo State University, Sao Jose do Rio Preto, São Paulo, Brazil.
Background: Estrogens are critical players in prostate growth and disease. Estrogen therapy has been the standard treatment for advanced prostate cancer for several decades; however, it has currently been replaced by alternative anti-androgenic therapies. Additionally, studies of its action on prostate biology, resulting from an association between carcinogens and estrogen, at different stages of life are scarce or inconclusive about its protective and beneficial role on induced-carcinogenesis.
View Article and Find Full Text PDF[Karyometry of BBN-induced precancerosis of the urothelium : An experimental analysis].
Urologe A
October 2016
Klinik und Poliklinik für Urologie, Hufelandstraße 55, 45147, Essen, Deutschland.
Background: The morphology of experimental precancerous lesions of the urinary bladder has been interpreted quite differently by various authors.
Objectives: The aim of this investigation was to quantify these lesions by karyometry and, thus, to gain a more reliable understanding of the process.
Materials And Methods: A total of 60 Wistar rats were fed with N‑butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at a concentration of 0.
Phase IIB Randomized Study of Topical Difluoromethylornithine and Topical Diclofenac on Sun-Damaged Skin of the Forearm.
Cancer Prev Res (Phila)
February 2016
Division of Hematology-Oncology, Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona.
Prevention of nonmelanoma skin cancers remains a health priority due to high costs associated with this disease. Diclofenac and difluoromethylornithine (DFMO) have demonstrated chemopreventive efficacy for cutaneous squamous cell carcinomas. We designed a randomized study of the combination of DFMO and diclofenac in the treatment of sun-damaged skin.
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