AI Article Synopsis
- The study aimed to evaluate the significance of serum biomarkers in diagnosing gestational trophoblastic disease (GTD) among pregnant women.
- Sixty-nine women with molar pregnancies were compared to nineteen healthy pregnant women, measuring various serum biomarkers, including hCG, AFP, and CA markers.
- Results indicated that low AFP and high CA 19-9 levels could aid in diagnosing molar pregnancies, whereas other biomarkers like CA 125 and CEA were not significantly useful.
Article Abstract
Objective: To determine the clinical importance of serum biomarkers in diagnosis of gestational trophoblastic disease (GTD).
Study Design: Sixty-nine pregnant women with molar pregnancy and 19 healthy pregnant women with corresponding age, gravity, parity and gestational age were matched. Serum levels of human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), CA 125, CA 19-9, CA 15-3, CA 242 and carcinoembryonic antigen (CEA) were measured using enzyme-linked immunosorbent assay (ELISA). Mean serum values were compared between the groups using Mann-Whitney, chi2 and paired t tests.
Results: AFP levels were higher in the control group. CA 19-9 serum values are increased in patients with GTD. Comparing mean CA 19-9 serum levels between the groups demonstrated a meaningful relation (p = 0.012). CA 125, CA 15-3, CA 242 and CEA are not affected by molar pregnancy, and no significant difference was observed between the groups.
Conclusion: Low AFP levels and increased CA 19-9 levels can be used as tumor markers in diagnosis of molar pregnancies in conjunction with clinical and sonographic findings and serum levels of hCG. Serum levels of CA 125, CA 15-3, CA 242 and CEA did not provide reliable information in diagnosis of GTD.
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