Hypospadias is a common condition affecting approximately one in 300 boys in Scotland. The functional and aesthetic outcome of the many different techniques of repair are being analysed in increasingly critical fashion. However, few techniques have been published with more than short-term follow-up data. The modified Bretteville technique is a two-stage technique that can be used for all degrees of severity of hypospadias. It has certain advantages over other single- and two-stage techniques. We present the midterm results of 74 hypospadias corrections performed by using the modified Bretteville technique. The majority of hypospadias were distal (93%), but the series includes patients with mid-shaft and proximal deformity. The mean follow-up period was 67 months (range: 5-126). The average number of procedures per patient was 2.35, and 78% of patients had only two procedures. The overall fistula rate was 5.4% and the stenosis rate was 6.8%, though this figure has fallen to 2.6% for the fistula rate (n=38) and 0% for the stenosis rate (n=38) over the most recent 5-year follow-up period. One patient needed re-repair using a Bracka technique. We believe that the modified Bretteville technique is a reliable technique for proximal, as well as distal, hypospadias with an excellent cosmetic outcome.
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http://dx.doi.org/10.1016/j.bjps.2008.11.075 | DOI Listing |
Mol Psychiatry
June 2017
Institut Pasteur de Lille, Lille, France.
A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting orthologs of 54 candidate risk genes within these loci for their ability to modify Tau neurotoxicity by quantifying the size of >6000 eyes. Besides Drosophila Amph (ortholog of BIN1), which we previously implicated in Tau pathology, we identified p130CAS (CASS4), Eph (EPHA1), Fak (PTK2B) and Rab3-GEF (MADD) as Tau toxicity modulators.
View Article and Find Full Text PDFNeurobiol Aging
March 2013
Inserm, UMR 837, Alzheimer & Tauopathies, Jean-Pierre Aubert Research Centre, Faculty of Medicine, Institute of Predictive Medicine and Therapeutic Research, Lille, France.
A prerequisite to dephosphorylation at Ser-Pro or Thr-Pro motifs is the isomerization of the imidic peptide bond preceding the proline. The peptidyl-prolyl cis/trans isomerase named Pin1 catalyzes this mechanism. Through isomerization, Pin1 regulates the function of a growing number of targets including the microtubule-associated tau protein and is supposed to be deregulated Alzheimer's disease (AD).
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
January 2013
Department of Plastic Surgery, Ward 11, Ulster Hospital, Dundonald, Belfast BT16 1RH, Northern Ireland, UK.
Background: Very few studies on long term evaluation of functional outcome following hypospadias reconstruction are available. Results from the modified Bretteville method have shown excellent cosmesis with a low risk of fistula and stenosis. This study addresses the question; do flow rates, quality of urinary stream and cosmesis change over time?
Methods: A sample of 18 patients who had undergone the 2 stage modified Bretteville technique between 1998 and 2004 were reviewed.
Plant Dis
January 2012
Université de Picardie Jules Verne, Laboratoire de Biologie des Entomophages, 80039 Amiens Cedex, France.
The effects of the infection of potato (Solanum tuberosum) plants by the nonpersistent Potato virus Y (PVY) were studied on the host plant colonization behavior of different colonizing (Myzus persicae) and noncolonizing (Aphis fabae, Brevicoryne brassicae, and Sitobion avenae) aphid species. The underlying questions of this study were to know how aphids respond when faced with PVY-infected plants and whether plant infection can modify the aphid behavior involved in PVY spread. Short-range orientation behavior was observed using a dual-choice set-up and aphid feeding behavior was monitored using the electrical penetration graph technique.
View Article and Find Full Text PDFAnn Occup Hyg
March 2011
INSERM, U1018, CESP Centre for research in epidemiology and population health, Epidemiology of occupational and social determinants of health team, Hôpital Paul Brousse, 94807 Villejuif, France.
Objectives: The association between workplace bullying and psychotropic drug use is not well established. This study was aimed at exploring the association between workplace bullying, and its characteristics, and psychotropic drug use and studying the mediating role of physical and mental health.
Methods: The study population consisted of a random sample of 3132 men and 4562 women of the working population in the south-east of France.
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