Background: Uterine bleeding frequently complicates gestational trophoblastic disease, particularly after uterine evacuation. Hysterectomy and other procedures used to control this bleeding incur significant risk and can limit fertility.
Case: We present a case of massive hemorrhage complicating uterine curettage performed for metastatic gestational trophoblastic disease. The patient's bleeding was controlled successfully by intrauterine tamponade performed using a balloon catheter. After catheter removal, she achieved complete disease remission.
Conclusion: Intrauterine balloon catheterization appears to be a promising alternative to control uterine hemorrhage and preserve fertility for young women undergoing treatment for gestational trophoblastic disease. Its use may help avoid invasive interventions, such as hysterectomy and embolization, currently used to control hemorrhage after uterine evacuation.
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http://dx.doi.org/10.1097/AOG.0b013e318193bff3 | DOI Listing |
Histochem Cell Biol
January 2025
Departments of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Antalya, Turkey.
Preeclampsia (PE) is a severe placental complication occurring after the 20th week of pregnancy. PE is associated with inflammation and an increased immune reaction against the fetus. TYRO3 and PROS1 suppress inflammation by clearing apoptotic cells.
View Article and Find Full Text PDFGinekol Pol
January 2025
Department of Obstetrics, Renmin Hospital of Wuhan University, Wuhan, China, China.
O: BJECTIVES: Circular RNAs (circRNAs) are known to be associated with the progression of gestational diabetes mellitus (GDM). Thus, the objective of this study was to unveil the influnce and potential mechanism of hsa_circ_0002768 in GDM. M: ATERIAL AND: METHODS: Levels of hsa_circ_0002768 were quantified by RT-qPCR.
View Article and Find Full Text PDFJ Cell Mol Med
February 2025
Department of Reproductive Health and Infertility, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China.
Reduced trophoblast migration and invasion contribute to unexplained recurrent spontaneous abortion (URSA). Aquaporin 3 (AQP3) plays a crucial role in facilitating trophoblast migration and invasion during early pregnancy through fetal-maternal crosstalk. This study aimed to comprehensively investigate the mechanism involving AQP3 and its modulatory effects on human extravillous trophoblast (HTR-8/SVneo cells) migration and invasion.
View Article and Find Full Text PDFInt J Gynecol Cancer
January 2025
Hospital 9 de Julho-Dasa Oncologia, São Paulo, Brazil.
The "Key Takeaways: Gynecological cancer breakthroughs at ESMO Congress 2024" aims to include the most original and potentially practice-changing research in gynecologic oncology presented during the Annual Congress of the European Society of Medical Oncology, held in Barcelona, Spain, September 13 to 17, 2024. The scientific program encompassed a wide range of topics across various fields within oncology, and we selected 13 studies presented during the conference considered highly significant in the field of gynecologic oncology.
View Article and Find Full Text PDFJ Psychosom Obstet Gynaecol
December 2025
Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, the Netherlands.
The diagnosis gestational trophoblastic disease (GTD) is known to have a significant psychological impact on women. Our objective was to provide insight in the psychological and physical consequences of women with GTD, while also reflecting on their coping strategies and their experiences of received care. A qualitative study was carried out using semi-structured interviews among women recently diagnosed with GTD.
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