Docetaxel-induced skin toxicity.

Neth J Med

Published: January 2009

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Article Synopsis
  • The rupture occurred mainly due to the use of a silicone catheter at an improper puncture angle, leading to extravasation of the drug docetaxel.
  • It emphasizes the importance of using polyurethane catheters to minimize rupture risks and urges nursing and clinical staff to be vigilant about recognizing signs of catheter-related complications and delayed skin toxicity from chemotherapy.
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Objective: Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn't have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.

Material And Methods: Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks.

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Characteristics of Developmental and Healing Process of Docetaxel-Induced Lower Limb Edema in Patients with Stage IV Breast Cancer: A Case Series.

Palliat Med Rep

February 2023

Department of Clinical Nursing, Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.

Background: Management of docetaxel-induced edema is important as severe edema may lead to discontinuation of chemotherapy. Patients with stage IV breast cancer (BC) treated with docetaxel have shown lower limb edema; however, details of its developmental and healing processes are unknown, and thus management strategies have not been established. The aim of this study was to investigate the characteristics of the development and healing process of docetaxel-induced lower limb edema in stage IV BC patients.

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