AI Article Synopsis
- DNA microarray and next-generation sequencing are key technologies for studying genomes, helping to uncover their structure and function.
- In the last decade, DNA microarrays have been widely used in functional genomics, systems biology, and pharmacogenomics, while next-generation sequencing rapidly evolved after its introduction in 2003.
- This paper reviews how these technologies work, their applications in genomics research, and their future prospects, highlighting the competition between the two methods.
Article Abstract
DNA microarray and next-generation DNA sequencing technologies are important tools for high-throughput genome research, in revealing both the structural and functional characteristics of genomes. In the past decade the DNA microarray technologies have been widely applied in the studies of functional genomics, systems biology and pharmacogenomics. The next-generation DNA sequencing method was first introduced by the 454 Company in 2003, immediately followed by the establishment of the Solexa and Solid techniques by other biotech companies. Though it has not been long since the first emergence of this technology, with the fast and impressive improvement, the application of this technology has extended to almost all fields of genomics research, as a rival challenging the existing DNA microarray technology. This paper briefly reviews the working principles of these two technologies as well as their application and perspectives in genome research.
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| http://dx.doi.org/10.1007/s11427-009-0012-9 | DOI Listing |
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