AI Article Synopsis
- 239 colorectal cancer patients underwent surgery and were given 5'-DFUR for either 1 year or 3 years, with a follow-up of at least five years.
- Survival rates were high for both groups, with the 3-year group showing slightly better results (92% vs. 91.4% at 5 years), although no significant difference was found statistically.
- The treatment was generally safe, with low rates of adverse effects (14.8% for the 1-year group and 19.5% for the 3-year group), indicating that 5'-DFUR is effective and safe for improving patient prognosis in colorectal cancer.
Article Abstract
Methods: Subjects were 239 patients with colorectal cancer who underwent curative resection surgery from December 1994 to March 1997(Stage I-III b). The patients were given 5'-DFUR for postoperative 10 months as scheduled. They had been allocated into either a 1-year group or a 3-year group by dynamic randomization. 5'-DFUR was administered by an intermittent regimen such as 1,200 mg/body/day for five days followed by two days rest. All patients were followed for five years at least.
Results: 239 patients were enrolled in the study. Favorable prognoses in both groups were observed. Although no statistically significant differences in overall survival curves of full analysis set based on the drug administration durations, were detected(log-rank test, p=0.734), a better prognosis was found in the 3-year group(5-year OS: 92.0%; 1- year group, 91.4%; 3-year group). Adverse drug reactions resulted in low rates such as 14.8% in the 1-year group and 19.5% in the 3-year group. Grade 3 was found in either group.
Conclusions: Due to a result in the present study that 5-year survival rates in both groups were far higher than anticipated, we could not finally clarify the optimal administration duration of 5'-DFUR. However, the results of the present study indicate that 5'-DFUR results in a good prognosis for colorectal cancer patients and is safe over a long / administration period.
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