T2* value measurement of the liver parenchyma with a 3.0T MR scanner may be useful for evaluating focal liver function. Currently, there are 2 sequences for measurement of T2* value of the liver: multi-echo fast field echo (mFFE), and multi-echo planar imaging (EPI). We can correct inhomogeneity of the local magnetic field with the EPI sequence; however, the spatial resolution is poor. On the other hand, mFFE has a relatively high spatial resolution but cannot correct inhomogeneity of the local magnetic field. We investigated the two measurement methods of a T2* map that measured the T2* images obtained with mFFE and EPI sequences by using a 3.0T MR scanner in the phantom and patient studies. In the phantom studies, T2* values measured on images with the mFFE sequence were affected by inhomogeneity of the local magnetic field, but T2* values measured on images with the EPI sequence were showed no difference by corrected inhomogeneity of local magnetic field. However, in the clinical study, we found good agreement in T2* values of the liver measured on images with mFFE and EPI sequences. Therefore, the mFFE sequence can be an alternative to the EPI sequence in the clinical setting. It is occasionally difficult to identify normal or pathological structures on images obtained with the EPI sequence because of its low spatial resolution. The spatial resolution of images obtained with the mFFE sequence is much better than that with the EPI sequence. Based on these discussions, we believe that the mFFE sequence may be appropriate for the measurement of T2* values in the liver in the clinical setting.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.6009/jjrt.64.1547 | DOI Listing |
Purpose: To develop a rapid, high-resolution and distortion-free quantitative $R_{2}^{*}$ mapping technique for fetal brain at 3 T.
Methods: A 2D multi-echo radial FLASH sequence with blip gradients is adapted for fetal brain data acquisition during maternal free breathing at 3 T. A calibrationless model-based reconstruction with sparsity constraints is developed to jointly estimate water, fat, $R_{2}^{*}$ and $B_{0}$ field maps directly from the acquired k-space data.
J Integr Bioinform
January 2025
Research Center for Molecular Biotechnology and Bioinformatics, Universitas Padjadjaran, Bandung 40133, Indonesia.
The emergence of new variants of SARS-CoV-2, including Alpha, Beta, Gamma, Delta, Omicron variants, and XBB sub-variants, contributes to the number of coronavirus cases worldwide. SARS-CoV-2 is a positive RNA virus with a genome of 29.9 kb that encodes four structural proteins: spike glycoprotein (S), envelope glycoprotein (E), membrane glycoprotein (M), and nucleocapsid glycoprotein (N).
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Epi Biotech Co., Ltd., Incheon 21983, Republic of Korea.
We previously demonstrated that C-X-C Motif Chemokine Ligand 12 (CXCL12) is primarily secreted by dermal fibroblasts in response to androgens and induces hair miniaturization in the mouse androgenic alopecia (AGA) model. However, the direct effects of androgen-induced CXCL12 on dermal papilla cells (DPCs) and dermal sheath cup cells (DSCs) have not been demonstrated. First, we compared single-cell RNA sequencing data between mouse and human skin, and the results show that CXCL12 is highly co-expressed with the androgen receptor (AR) in the DPCs and DSCs of only human hair.
View Article and Find Full Text PDFChemMedChem
January 2025
Universitatsspital Basel, Radiopharmazeutische Chemie, Petersgraben 4, 4031, Basel, SWITZERLAND.
The C-X-C chemokine receptor 4 (CXCR4) is highly upregulated in most cancers, making it an ideal target for delivering radiation therapy to tumors. We previously demonstrated the feasibility of targeting CXCR4 in vivo using a radiolabeled derivative of EPI-X4, an endogenous CXCR4 antagonist, named DOTA-K-JM#173. However, this derivative showed undesirable accumulation in the kidneys, which would limit its clinical use.
View Article and Find Full Text PDFNeuroimage
January 2025
School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, PR China. Electronic address:
Background: Although epigenomic and environment interactions (Epigenome × Environment; Epi × E) might constitute a novel mechanism underlying reward processing, direct evidence is still scarce. We conducted the first longitudinal study to investigate the extent to which DNA methylation of a stress-related gene-NR3C1-interacts with childhood maltreatment in association with young adult reward responsiveness (RR) and the downstream risk of depressive (anhedonia dimension in particular) and anxiety symptoms.
Method: A total of 192 Chinese university students aged 18∼25 (M = 21.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!