AI Article Synopsis
- The study focuses on analyzing tumor characteristics and treatment patterns in elderly breast cancer patients aged 60 and above.
- Elderly patients presented with larger tumors and more favorable biological profiles, such as higher estrogen/progesterone positivity and lower c-erbB2 positivity.
- The findings indicate that older women are more likely to receive less aggressive treatments, including fewer adjuvant therapies, compared to younger patients, despite having tumors that may be biologically more favorable.
Article Abstract
The aims of this study are to describe tumor characteristics and treatment patterns of elder breast cancer patients and to determine the factors influencing local and systemic treatments. This retrospective cohort included 866 patients (>or=60 years) referred for surgery between January 2002 and December 2006. The patients were divided into four groups according to age. Elderly women had larger tumors at diagnosis with more mucinous carcinomas, more estrogen/progesterone-positive, lower Ki-67 labeling indices and less c-erbB2 positive tumors. Comorbidities were more often recorded for older patients. They were more likely to undergo simple mastectomy or breast-conserving surgery, less likely to receive adjuvant chemotherapy and radiotherapy, compared with their younger counterparts. Multinomial and binary logistic regression showed that age was independently associated with local and systemic treatments. Our data suggest that the tumors of elderly patients are biologically more favorable, and elderly women appear to receive less aggressive treatments.
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| http://dx.doi.org/10.1016/j.critrevonc.2008.11.005 | DOI Listing |
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