BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20min cat exposure were calculated. At higher doses (15 or 30microg/kg) but not lower doses (0.1-1microg/kg) BC264 statistically significantly decreased freezing compared to control (p<0.001).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.peptides.2008.12.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sex-dependent modification by chronic caffeine of acute methamphetamine effects on anxiety-related behavior in rats.
Behav Brain Res
June 2018
Department of Psychology, University of Canterbury, Christchurch, 8140, New Zealand.
For fourteen days, male and female PVG/c hooded rats were provided continuously with either pure drinking water, or water containing caffeine in a quantity approximating a daily dose of 31.1 mg/kg. Then at intervals of 3 days, they were administered 1, 2 mg/kg methamphetamine (MA) or saline before being tested for anxiety-related behavior in a zero maze or a light/dark box, or their short-term spatial memory was assessed in a Y maze following introduction of a novel brightness change in one of the arms.
View Article and Find Full Text PDFEffects of acute caffeine on anxiety-related behavior in rats chronically exposed to the drug, with some evidence of possible withdrawal-reversal.
Behav Brain Res
March 2017
Department of Psychology, University of Canterbury, Christchurch 8140, New Zealand.
For 20days male and female PVG/c hooded rats were provided with caffeinated (approximately 50mg/kg/day) or unadulterated drinking water, and then their anxiety-related behavior was observed in an open field and elevated plus maze. Their choices of a brightness change were also observed in a Y maze to assess any caffeine effects on spatial memory. 24h later, all rats were tested again following an intraperitoneal injection of 50mg/kg acute caffeine, or vehicle.
View Article and Find Full Text PDFAnxiolytic effects of environmental enrichment attenuate sex-related anxiogenic effects of scopolamine in rats.
Prog Neuropsychopharmacol Biol Psychiatry
January 2013
Department of Psychology, University of Canterbury, Christchurch, New Zealand.
In groups of four same-sexed animals, PVG/c hooded rats were housed for 4.5 months in standard or enriched cages containing several objects that could be explored and manipulated. On separate occasions, each rat then experienced two consecutive daily trials in an open field, a light-dark box or a Y maze with arm inserts that enabled an acquisition trial comprising one black and one white arm to be changed for a retention trial consisting of two black arms.
View Article and Find Full Text PDFThe CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat.
Peptides
April 2009
Department of Pharmacology, National University of Singapore, Singapore.
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.
View Article and Find Full Text PDFIs survival time after hemorrhage a heritable, quantitative trait?: an initial assessment.
Shock
June 2008
US Army Institute of Surgical Research, 3400 Rawley E. Chambers Avenue, Fort Sam Houston, TX 78234, USA.
Enhancing survival to hemorrhage of both civilian and military patients is a major emphasis for trauma research. Previous observations in humans and outbred rats show differential survival to similar levels of hemorrhage. In an initial attempt to determine potential genetic components of such differential outcomes, survival time after a controlled hemorrhage was measured in 15 inbred strains of rats.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!