Presumed topiramate-induced maculopathy.

Epilepsy Behav

Service de Neurologie, Centre Hospitalier de Luxembourg, Rue Barblé 4, L-1210 Luxembourg, Luxembourg.

Published: March 2009

AI Article Synopsis

  • - A patient experienced decreased vision while on topiramate (TPM) for epilepsy, leading to an ophthalmological exam that indicated maculopathy.
  • - After discontinuing TPM, the patient's vision did not show significant improvement over six months.
  • - The authors speculate that TPM may have caused maculopathy, similar to how vigabatrin can lead to retinal toxicity and lasting visual issues.

Article Abstract

The case of a patient who developed decreased vision while taking topiramate (TPM) for symptomatic epilepsy is described. Ophthalmological examination revealed findings suggestive of maculopathy. TPM was discontinued; however, vision failed to improve significantly over 6 months of follow-up. We hypothesize that the patient's maculopathy was induced by TPM. TPM, like vigabatrin, may exert retinal toxicity causing persistent visual impairment.

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Source
http://dx.doi.org/10.1016/j.yebeh.2008.12.015DOI Listing

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