AI Article Synopsis
- Echinocandins, like micafungin, are promising treatments for invasive fungal infections in patients with weakened immune systems after intensive chemotherapy or stem cell transplants.
- Two patients with blood disorders experienced severe breakdown of red blood cells and subsequent kidney failure after receiving micafungin.
- The tests showed that micafungin triggered an immune response, producing antibodies that attacked both micafungin and the patients' red blood cells, leading to this serious and rare reaction.
Article Abstract
The echinocandins provide an attractive new option for prophylactic and empirical treatment of invasive fungal infections in patients with neutropenia after intensive cytotoxic chemotherapy or hematopoietic stem cell transplantation. We present two patients with hematological diseases who experienced massive intravascular hemolysis followed by renal failure after administration of micafungin. In indirect antiglobulin test, significant agglutination was observed when red blood cells were exposed to the mixture of micafungin and either of the patients' plasma samples, indicating that production of antibodies directed against both micafungin and red blood cell membrane induced hemolysis attack. Micafungin-mediated immune hemolysis represents an uncommon but life-threatening adverse reaction leading to renal failure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12185-008-0246-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!